869-07-8

Basic information

• Product Name: N1-ISOPROPYL-2-METHYLPROPANAMIDE
• Synonyms: N1-ISOPROPYL-2-METHYLPROPANAMIDE;N-isopropylisobutyramide;2-Methyl-N-(1-methylethyl)propanamide;PropanaMide, 2-Methyl-N-(1-Methylethyl)-;N-Isopropyl-2-methylpropanamide;PROPANAMIDE,2-METHYL-N- (ISOPROPYL)-
• CAS NO: 869-07-8
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.2
• Mol File: 869-07-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 103 °C
• Boiling Point: 209℃
• Flash Point: 111℃
• Appearance: /
• Density: 0.856
• Vapor Pressure: 0.211mmHg at 25°C
• Refractive Index: 1.418
• CAS DataBase Reference: N1-ISOPROPYL-2-METHYLPROPANAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N1-ISOPROPYL-2-METHYLPROPANAMIDE(869-07-8)
• EPA Substance Registry System: N1-ISOPROPYL-2-METHYLPROPANAMIDE(869-07-8)

Safety Data

• Hazardous Substances Data: 869-07-8(Hazardous Substances Data)

Usage

General Description

N1-Isopropyl-2-methylpropanamide, also known as N-isopropylisobutyramide, is a chemical compound with the formula C7H15NO. It is a derivative of isobutyramide and isopropylamine. N1-ISOPROPYL-2-METHYLPROPANAMIDE is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is a colorless, odorless liquid with a boiling point of 160-163°C and a molecular weight of 129.20 g/mol. N1-Isopropyl-2-methylpropanamide is also used as a solvent in various industrial processes and as a reagent in organic chemistry reactions. Additionally, it has applications in the cosmetics and personal care industry, serving as an emollient and viscosity controlling agent in beauty and skincare products.

InChI:InChI=1/C7H15NO/c1-5(2)7(9)8-6(3)4/h5-6H,1-4H3,(H,8,9)

Upstream product

• 1113-74-2 diisopropyl ketone oxime 
• 5338-14-7 2,4-dimethyl-pentan-3-one semicarbazone 
• 7664-93-9 sulfuric acid 
• 81171-27-9 N-(3-Chloro-2-butylidene)isopropylamine 
• 75-65-0 tert-butyl alcohol 
• 865-47-4 potassium tert-butylate 
• 6918-58-7 Dimethyl (2-methyl-1-oxopropyl)phosphonate 

Downstream Products

• 39099-24-6 N-isopropyl-2-methylpropan-1-amine 

Relevant articles and documents

Bromodimethylsulfonium bromide (BDMS) in ionic liquid: a mild and efficient catalyst for Beckmann rearrangement

Bromodimethylsulfonium bromide (BDMS)-catalyzed Beckmann rearrangement of a variety of ketoximes has been carried out in the imidazolium-based ionic liquid [bmim]PF6 under mild conditions without using any additional cocatalyst or solvent to afford excellent conversion and selectivity. The ionic liquid is recovered and reused for up to three runs without any loss of efficiency.

The Favorskii Rearrangement of α-Chloro Ketimines

The Favorskii rearrangement of α-chloro ketimines has been studied.It was shown that the base-induced rearrangement of α-chloro ketimines afforded imidates or amides via a mechanism involving 1,3-dehydrochlorination and ring-opening of the resulting cyclopropylideneamines.The ring-opening occurred in such a way as to produce the most stable carbanion.The entire mechanism paralleled the well-known cyclopropanone mechanism of the Favorskii rearrangement of the corresponding oxygen analogues, i.e., α-halo ketones.Evidence has been presented that the semibenzilic-type mechanism is not operative in the cases studied.Depending upon the reaction conditions and the substrate, the Favorskii rearrangement was accompanied by various side reactions including nucleophilic substitution, 1,2-dehydrochlorination, rearrangement via intermediate α-alkoxyaziridines, and self-condensation.