870604-65-2

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870604-65-2

Product Name:Benzoic acid, 2-[(1,2,3,4-tetrahydro-3-oxo-6-quinoxalinyl)carbonyl]-
CAS Number: 870604-65-2
EINECS:
Molecular Weight:296.282
Molecular Formula: C16H12N2O4
HS Code:
Mol File:870604-65-2.mol

Synonyms:

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Relevant articles and documentsAll total 1 Articles be found

RAF MODULATORS AND METHODS OF USE

-

, (2010/02/14)

The present invention relates to compounds of the Formula I, wherein G, A, X1, X2, X3, Z, E, Y, and X are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Raf. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.

Process route upstream and downstream products

Process route

: phenylmethyl 2-{[3-nitro-4-({2-oxo-2-[(phenylmethyl)oxy]ethyl}amino)phenyl]carbonyl}benzoate

: 870604-65-2
2-[(3-oxo-1,2,3,4-tetrahydroquinoxalin-6-yl)carbonyl]benzoic acid

Conditions

Conditions	Yield
With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; ethyl acetate; under 2068.65 Torr;

: 85-54-1
2-(4'-chloro-3'-nitrobenzoyl)benzoic acid

: 870604-65-2
2-[(3-oxo-1,2,3,4-tetrahydroquinoxalin-6-yl)carbonyl]benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: potassium hydroxide; water / 15 h / 90 °C 1.2: pH ~ 5 2.1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C 3.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethyl acetate / 2068.65 Torr With potassium hydroxide; water; hydrogen; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

Yield

Multi-step reaction with 3 steps

1.1: potassium hydroxide; water / 15 h / 90 °C

1.2: pH ~ 5

2.1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethyl acetate / 2068.65 Torr

With potassium hydroxide; water; hydrogen; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

: 2-({4-[(carboxymethyl)amino]-3-nitrophenyl}carbonyl)benzoic acid

: 870604-65-2
2-[(3-oxo-1,2,3,4-tetrahydroquinoxalin-6-yl)carbonyl]benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C 2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethyl acetate / 2068.65 Torr With hydrogen; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

: 870604-65-2
2-[(3-oxo-1,2,3,4-tetrahydroquinoxalin-6-yl)carbonyl]benzoic acid

: 108-42-9
3-chloro-aniline

: 7-[2-(3-chlorophenyl)-1-hydroxy-3-oxo-2,3-dihydro-1H isoindol-1-yl]-3,4-dihydroquinoxalin-2(1H)-one

Conditions

Conditions	Yield
2-[(3-oxo-1,2,3,4-tetrahydroquinoxalin-6-yl)carbonyl]benzoic acid; With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h; 3-chloro-aniline; In N,N-dimethyl-formamide; at 20 ℃; for 15h;	39%

: 870604-65-2
2-[(3-oxo-1,2,3,4-tetrahydroquinoxalin-6-yl)carbonyl]benzoic acid

: 18107-18-1
diazomethyl-trimethyl-silane

: methyl 2-[(3-oxo-1,2,3,4-tetrahydroquinoxalin-6-yl)carbonyl]benzoate

Conditions

Conditions	Yield
2-[(3-oxo-1,2,3,4-tetrahydroquinoxalin-6-yl)carbonyl]benzoic acid; diazomethyl-trimethyl-silane; In methanol; hexane; benzene; With acetic acid; In methanol; hexane; benzene;

870604-65-2 Upstream products

85-54-1
2-(4'-chloro-3'-nitrobenzoyl)benzoic acid

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Cas Database

870604-65-2

870604-65-2

Identification

Product Name:Benzoic acid, 2-[(1,2,3,4-tetrahydro-3-oxo-6-quinoxalinyl)carbonyl]-

CAS Number: 870604-65-2

EINECS:

Molecular Weight:296.282

Molecular Formula: C16H12N2O4

HS Code:

Mol File:870604-65-2.mol

Synonyms:

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Chemical Properties

Safety information and MSDS

Supplier and reference price view more

Relevant articles and documentsAll total 1 Articles be found

RAF MODULATORS AND METHODS OF USE

-

, (2010/02/14)

Process route upstream and downstream products

Process route

870604-65-2 Upstream products

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Remarks: The blank with*must be completed