873943-00-1

Basic information

• Product Name: N-(3-chlorophenyl)-6-(trifluoromethyl)quinolin-4-amine
• Synonyms: N-(3-chlorophenyl)-6-(trifluoromethyl)quinolin-4-amine
• CAS NO: 873943-00-1
• Molecular Weight: 322.717
• Mol File: 873943-00-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(3-chlorophenyl)-6-(trifluoromethyl)quinolin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-chlorophenyl)-6-(trifluoromethyl)quinolin-4-amine(873943-00-1)
• EPA Substance Registry System: N-(3-chlorophenyl)-6-(trifluoromethyl)quinolin-4-amine(873943-00-1)

Safety Data

• Hazardous Substances Data: 873943-00-1(Hazardous Substances Data)

Upstream product

• 49713-56-6 4-chloro-6-(trifluoromethyl)quinoline 
• 108-42-9 3-chloro-aniline 

Relevant articles and documents

Identification and evaluation of 4-anilinoquin(az)olines as potent inhibitors of both dengue virus (DENV) and Venezuelan equine encephalitis virus (VEEV)

There is an urgent need for novel strategies for the treatment of emerging arthropod-borne viral infections, including those caused by dengue virus (DENV) and Venezuelan equine encephalitis virus (VEEV). We prepared and screened focused libraries of 4-anilinoquinolines and 4-anilinoquinazolines for antiviral activity and identified three potent compounds. N-(2,5-dimethoxyphenyl)-6-(trifluoromethyl)quinolin-4-amine (10) inhibited DENV infection with an EC50 = 0.25 μM, N-(3,4-dichlorophenyl)-6-(trifluoromethyl)quinolin-4-amine (27) inhibited VEEV with an EC50 = 0.50 μM, while N-(3-ethynyl-4-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine (54) inhibited VEEV with an EC50 = 0.60 μM. These series of compounds demonstrated nearly no toxicity with CC50 values greater than 10 μM in all cases. These promising results provide a future prospective to develop a clinical compound against these emerging viral threats.

METHODS AND COMPOSITIONS FOR THE TREATMENT OF BODY COMPOSITION DISORDERS

This invention relates to methods of treating, managing and preventing body composition disorders, and to compounds and pharmaceutical compositions useful in such methods.