876-27-7

Basic information

• Product Name: 4-CHLOROPHENOL ACETATE
• Synonyms: Acetic acid, p-chlorophenyl ester;aceticacid,4-chlorophenylester;aceticacid,p-chlorophenylester;p-Acetoxychlorobenzene;p-Chlorfenylester kyseliny octove;p-chlorfenylesterkyselinyoctove;p-chloro-phenoacetate;p-Chlorophenyl acetate
• CAS NO: 876-27-7
• Molecular Formula: C₈H₇ClO₂
• Molecular Weight: 170.59
• Mol File: 876-27-7.mol
• Article Data: 151

Chemical Properties

• Boiling Point: 231.6°Cat760mmHg
• Flash Point: 106.3°C
• Appearance: /
• Density: 1.227g/cm³
• Vapor Pressure: 0.0616mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-CHLOROPHENOL ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLOROPHENOL ACETATE(876-27-7)
• EPA Substance Registry System: 4-CHLOROPHENOL ACETATE(876-27-7)

Safety Data

• Hazardous Substances Data: 876-27-7(Hazardous Substances Data)

Usage

General Description

4-Chlorophenol acetate is a complex organic synthetic chemical compound comprising elements like chlorine, phenol, and acetate. The chemical, which can also be referred to as p-chlorophenol acetate or para-Chlorophenyl acetate, exists as a white crystalline solid structure at room temperature but is soluble in alcohol and ether. Its key applications are typically in the field of organic chemistry as a reagent or intermediate in various chemical reactions and synthesis. Like many chlorinated aromatic compounds, it may have toxic properties and its handling requires appropriate safety measures.

InChI:InChI=1/C8H7ClO2/c1-6(10)11-8-4-2-7(9)3-5-8/h2-5H,1H3

Upstream product

• 108-24-7 acetic anhydride 
• 106-48-9 4-chloro-phenol 
• 878-00-2 4-formylphenyl acetate 
• 24573-38-4 4-chlorophenolate 
• 1523-06-4 3-nitrophenyl acetate 
• 13122-34-4 1-chloro-4-deuterio-benzene 
• 127-09-3 sodium acetate 
• 99-91-2 para-chloroacetophenone 
• 64-19-7 acetic acid 
• 108-90-7 chlorobenzene 
• 623-12-1 4-chloromethoxybenzene 
• 17005-59-3 4-chlorophenoxytrimethylsilane 
• 506-96-7 Acetyl bromide 
• 7700-27-8 4-chlorophenyl benzyl ether 

Downstream Products

• 3027-06-3 1-acetylpyrrolidine-2,5-dione 
• 24573-38-4 4-chlorophenolate 
• 71-50-1 acetate 
• 92-88-6 4,4'-Dihydroxybiphenyl 
• 88-87-9 4-chloro-2,6-dinitrophenol 
• 123871-57-8 4-chloro-4-nitrocyclohexa-2,5-dienone 
• 64-19-7 acetic acid 
• 106-48-9 4-chloro-phenol 
• 32604-29-8 4,4'-diacetoxybiphenyl 
• 122-79-2 Phenyl acetate 
• 588-46-5 N-(phenylmethyl)acetamide 
• 16197-92-5 (R)-1-phenethyl acetate 
• 98-86-2 acetophenone 
• 1517-68-6 (S)-1-phenylpropan-2-ol 

Relevant articles and documents

Activation parameters of transesterification of 4-nitrophenyl acetate in the presence of k2co3 in DMF

The activation parameters for the reactions of 4-nitrophenyl acetate with 4-chlorophenol and benzenethiol in the presence of potassium carbonate in dimethylformamide were determined. Depending on the substrate structure, the enthalpy and entropy of activa

Magnetically recyclable silica-coated ferrite magnetite-K10montmorillonite nanocatalyst and its applications in O, N, and S-acylation reaction under solvent-free conditions

Novel silica-coated ferrite nanoparticles supported with montmorillonite (K10) have been prepared successfully by using a simple impregnation method. Further, these nanoparticles were characterized by using different analytical methods like FT-IR, PXRD, EDS, and FE-SEM techniques. In addition, these nanoparticles have been explored for their catalytic activity for the O, N, and S-acylation reactions under solvent-free conditions which gave moderate to excellent yields in a much shorter reaction time. Moreover, these nanoparticles could easily be separated out from the reaction medium after the reaction completion by using an external magnetic field and have been re-used for 10 cycles without any significant loss of the catalytic activity.

Method for promoting acylation of amine or alcohol by carbon dioxide

The invention relates to a method for promoting acylation of amine or alcohol by carbon dioxide, which comprises the following steps of: mixing an amine compound, carboxylate or thiocarboxylate compound and a reaction solvent under the action of carbon dioxide, and reacting to obtain an amide compound, or under the action of carbon dioxide, mixing the alcohol compound, the thiocarboxylate compound and the reaction solvent [gamma]-valerolactone, and reacting to obtain the ester compound. According to the invention, under the promotion action of carbon dioxide, carboxylate or thiocarboxylate is used as an acylation reagent, and amine and alcohol are converted into amide and ester compounds in the absence of a transition metal catalyst, so that acylation reagents such as acyl chloride or anhydride with irritation and corrosivity are avoided; and the method has the advantages of simple operation, mild reaction conditions, high tolerance of substrate functional groups, strong applicability and high yield, and provides an efficient, reliable and economical preparation method for synthesis of amide and ester compounds.