87629-98-9Relevant articles and documents
Hexafluoroisopropanol-Promoted Haloamidation and Halolactonization of Unactivated Alkenes
Qi, Chenxiao,Force, Guillaume,Gandon, Vincent,Leb?uf, David
supporting information, p. 946 - 953 (2020/12/01)
Pyrrolidine and piperidine derivatives bearing halide functional groups are prevalent building blocks in drug discovery as halides can serve as an anchor for post-modifications. In principle, one of the simplest ways to build these frameworks is the haloa
Esterification of the olefine acid bromine in a preparation method (by machine translation)
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Paragraph 0010; 0011, (2018/01/11)
The invention relates to shown in the following formula of esterification of the olefine acid bromine in preparation method: The method comprises the steps: in - 78 °C first will be dimethyl sulfoxide (1.5 eq) methylene dichloride solution of instillment
Vanadium (V) oxide mediated bromolactonization of alkenoic acids
Campbell, McKenzie L.,Rackley, Samuel A.,Giambalvo, Lauren N.,Whitehead, Daniel C.
, p. 3895 - 3902 (2015/06/02)
A full account of our recently communicated method for the V2O5 mediated bromolactonization of alkenoic acids is presented. Here we describe the extensive evaluation of the metal oxide catalyst, terminal oxidant, halide source, solvent system, and reaction temperature that resulted in optimal conditions employing 0.05 equiv V2O5, 3 equiv urea-hydrogen peroxide complex (UHP), and 3 equiv of NH4Br in an acetone:H2O (6:1) solvent system at room temperature. Additionally, we have expanded the substrate scope of the reaction with the aim of evaluating the functional group tolerance of the transformation. Further, we present preliminary data of a related halogenation of β-diketones with our optimal conditions. Finally, we probed the role of urea in the transformation.
