876379-86-1

Basic information

• Product Name: 1-(2,3-difluorophenyl)piperazine
• Synonyms: 1-(2,3-difluorophenyl)piperazine
• CAS NO: 876379-86-1
• Molecular Formula: C₁₀H₁₂F₂N₂
• Molecular Weight: 198.2124864
• Mol File: 876379-86-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2,3-difluorophenyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,3-difluorophenyl)piperazine(876379-86-1)
• EPA Substance Registry System: 1-(2,3-difluorophenyl)piperazine(876379-86-1)

Safety Data

• Hazardous Substances Data: 876379-86-1(Hazardous Substances Data)

Upstream product

• 110-85-0 piperazine 
• 1489-53-8 1,2,3-trifluorobenzene 
• 38573-88-5 1-bromo-2,3-difluorobenzene 

Downstream Products

• 1027492-92-7 {2-amino-4-[(4-(2,3-difluorophenyl)piperazin-1-yl)methyl]thiophen-3-yl}(4-chlorophenyl)methanone 
• 1355156-01-2 2-{3-(4-chlorobenzoyl)-4-[(4-(2,3-difluorophenyl)piperazin-1-yl)methyl]thiophen-2-yl}-isoindole-1,3-dione 
• 876379-85-0 4-[4-(2,3-difluorophenyl)piperazin-1-yl]butylamine 
• 946522-91-4 tert-butyl ester of {2-[4-(2,3-difluorophenyl)piperazin-1-yl]-2-oxoethyl}carbamic acid 
• 934964-21-3 4-[4-(2,3-difluorophenyl)piperazin-1-yl]butyronitrile 

Relevant articles and documents

Microwave-assisted amination from fluorobenzenes without catalyst and strong base

A facile and versatile amination of fluorobenzenes has been developed in good to excellent yields under microwave irradiation in N-methylpyrrolidinone (NMP) without strong base and catalyst. The presence of additional halogen atom(s) enhanced the leaving ability of fluorine and meta fluorine gave higher activation than the ortho. It is remarkable that 1,2,3-trifluorobenzene, 1,2,4-trifluorobenzene and 1,2,4,5-tetrafluorobenzene can produce the regioselective mono-substituted products.

INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF

The invention relates to neuroreceptor-active carboxamide-substituted indolizine derivatives of general formula (I) wherein X represents a group of general formula (X1).