87641-61-0

Basic information

• Product Name: 3-pyridinealdoxime
• Synonyms: 3-pyridinealdoxime
• CAS NO: 87641-61-0
• Molecular Weight: 122.126
• Mol File: 87641-61-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-pyridinealdoxime(CAS DataBase Reference)
• NIST Chemistry Reference: 3-pyridinealdoxime(87641-61-0)
• EPA Substance Registry System: 3-pyridinealdoxime(87641-61-0)

Safety Data

• Hazardous Substances Data: 87641-61-0(Hazardous Substances Data)

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 

Downstream Products

• 1334840-74-2 (Z)-N'-methoxy-N-methyl-N-(2-phenylethyl)pyridine-3-carboximidamide 
• 1334840-77-5 (E)-N-[(Z)-methoxyimino-3-pyridylmethyl]-N-methylcinnamamide 
• 1334840-80-0 (E)-N-butyl-N-[(Z)-methoxyimino-3-pyridylmethyl]cinnamamide 
• 1334840-83-3 (E)-N-[(Z)-methoxyimino-3-pyridylmethyl]-N-methyl-3-(4-chlorophenyl)propenamide 
• 1334840-85-5 N-[(Z)-methoxyimino-3-pyridylmethyl]-N-methylbenzamide 
• 1334840-91-3 N-[(Z)-methoxyimino-3-pyridylmethyl]-N-methylphenylacetamide 
• 1334840-93-5 N-[(Z)-methoxyimino-3-pyridylmethyl]-N-methyl-2-phenoxyacetamide 
• 1334840-58-2 (Z)-N-benzyl-N'-hydroxy-N-methylpyridine-3-carboximidamide 
• 1334840-64-0 (Z)-N'-hydroxy-N-methyl-N-(2-phenylethyl)pyridine-3-carboximidamide 
• 1334840-70-8 (Z)-N-benzyl-N'-methoxy-N-methylpyridine-3-carboximidamide 

Relevant articles and documents

Design, synthesis, and structure-activity relationships of 3,4,5-trisubstituted 4,5-dihydro-1,2,4-oxadiazoles as TGR5 agonists

Given its role in the mediation of energy and glucose homeostasis, the G-protein-coupled bile acid receptor1 (TGR5) is considered a potential target for the treatment of type2 diabetes mellitus and other metabolic disorders. By thorough analysis of diverse structures of published TGR5 agonists, a hypothetical ligand-based pharmacophore model was built, and a new class of potent TGR5 agonists, based on the novel 3,4,5-trisubstituted 4,5-dihydro-1,2,4-oxadiazole core, was discovered by rational design. Three distinct synthetic methods for constructing 4,5-dihydro-1,2,4-oxadiazoles and extensive structure-activity relationship studies are reported herein. Compound (R)-54n, the structure of which was determined by single-crystal X-ray diffraction and quantum chemical solid-state TDDFT-ECD calculations, showed the best potency, with an EC50 value of 1.4nM toward hTGR5. Its favorable properties invitro warrant further investigation.