87666-83-9

Basic information

• Product Name: (R)-3-Methyl-2-{[1-thiophen-2-yl-meth-(E)-ylidene]-amino}-butan-1-ol
• Synonyms: (R)-3-Methyl-2-{[1-thiophen-2-yl-meth-(E)-ylidene]-amino}-butan-1-ol
• CAS NO: 87666-83-9
• Molecular Weight: 197.301
• Mol File: 87666-83-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-3-Methyl-2-{[1-thiophen-2-yl-meth-(E)-ylidene]-amino}-butan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-Methyl-2-{[1-thiophen-2-yl-meth-(E)-ylidene]-amino}-butan-1-ol(87666-83-9)
• EPA Substance Registry System: (R)-3-Methyl-2-{[1-thiophen-2-yl-meth-(E)-ylidene]-amino}-butan-1-ol(87666-83-9)

Safety Data

• Hazardous Substances Data: 87666-83-9(Hazardous Substances Data)

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 4276-09-9 (R)-2-amino-3-methylbutanol 

Downstream Products

• 82417-08-1 N-2'-hydroxy-1'-isopropylethyl-2-(4-methoxyphenyl)-1-(2-thienyl)ethylamine 
• 82417-05-8 (R)-3-Methyl-2-((R)-2-phenyl-1-thiophen-2-yl-ethylamino)-butan-1-ol 

Relevant articles and documents

Discovery of 2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5-methylfuran-2-yl) propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): A potent, orally bioavailable CXCR2/CXCR1 receptor antagonist

Structure-activity studies on lead cyclobutenedione 3 led to the discovery of 4 (SCH 527123), a potent, orally bioavailable CXCR2/CXCR1 receptor antagonist with excellent cell-based activity. Compound 4 displayed good oral bioavailability in rat and may be a potential therapeutic agent for the treatment of various inflammatory diseases.