87702-21-4

Basic information

• Product Name: 4-(thien-2-yl)-4-oxobutyric acid methyl ester
• Synonyms: 4-(thien-2-yl)-4-oxobutyric acid methyl ester
• CAS NO: 87702-21-4
• Molecular Weight: 198.243
• Mol File: 87702-21-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(thien-2-yl)-4-oxobutyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(thien-2-yl)-4-oxobutyric acid methyl ester(87702-21-4)
• EPA Substance Registry System: 4-(thien-2-yl)-4-oxobutyric acid methyl ester(87702-21-4)

Safety Data

• Hazardous Substances Data: 87702-21-4(Hazardous Substances Data)

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 292638-85-8 acrylic acid methyl ester 

Downstream Products

• 116539-55-0 (S)-3-methylamino-1-(2-thienyl)-1-propanol 
• 85312-06-7 4-[1-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-2,5-dioxo-pyrrolidin-(3Z)-ylidene]-4-thiophen-2-yl-butyric acid 
• 85312-09-0 4-[5,8-Dioxo-1-phenyl-7,8-dihydro-1H-pyrazolo[1,2-a]pyridazin-(6Z)-ylidene]-4-thiophen-2-yl-butyric acid 
• 85312-05-6 4-[2,5-Dioxo-1-{[1-phenyl-meth-(E)-ylidene]-amino}-pyrrolidin-(3Z)-ylidene]-4-thiophen-2-yl-butyric acid 
• 54558-07-5 6-(thien-2-yl)-2,3-dihydropyridazin-3-one 
• 4653-11-6 2-thiophenebutyric acid 
• 52240-00-3 6-(thien-2-yl)-2,3,4,5-tetrahydropyridazin-3-one 

Relevant articles and documents

Stetter reaction in room temperature ionic liquids and application to the synthesis of haloperidol

Imidazolium-type room temperature ionic liquids (RTILs) have been used for the Stetter reaction, affording the desired 1,4-dicarbonyl compounds in good yields. Thiazolium salts and Et3N are efficient catalysts for this reaction performed in ionic liquid. The possibility to recycle and reuse the solvent has been demonstrated, although it was not possible to recycle the thiazolium catalyst. This method was used in the total synthesis of haloperidol.