879395-81-0

Basic information

• Product Name: Carbamic acid, [(1S)-1-[(1R)-1-hydroxy-2-oxo-2-[[(1R)-1-phenylethyl]amino]ethyl]pentyl]- , (3S)-4,4-dimethyl-3-pyrrolidinyl ester
• CAS NO: 879395-81-0
• Molecular Formula: C22H35N3O4
• Molecular Weight: 405.538
• Mol File: 879395-81-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S)-1-[(1R)-1-hydroxy-2-oxo-2-[[(1R)-1-phenylethyl]amino]ethyl]pentyl]- , (3S)-4,4-dimethyl-3-pyrrolidinyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-1-[(1R)-1-hydroxy-2-oxo-2-[[(1R)-1-phenylethyl]amino]ethyl]pentyl]- , (3S)-4,4-dimethyl-3-pyrrolidinyl ester(879395-81-0)
• EPA Substance Registry System: Carbamic acid, [(1S)-1-[(1R)-1-hydroxy-2-oxo-2-[[(1R)-1-phenylethyl]amino]ethyl]pentyl]- , (3S)-4,4-dimethyl-3-pyrrolidinyl ester(879395-81-0)

Safety Data

• Hazardous Substances Data: 879395-81-0(Hazardous Substances Data)

Upstream product

• 79-50-5 (S)-pantolactone 
• 144043-26-5 (3S)-N-benzyl-4,4-dimethyl-3-hydroxypyrrolidine 
• 137161-74-1 (2S)-3,3-dimethylbutane-1,2,4-triol 
• 511268-36-3 Methanesulfonic acid (S)-3-hydroxy-4-methanesulfonyloxy-2,2-dimethyl-butyl ester 
• 879395-79-6 {(S)-1-[(R)-Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-pentyl}-carbamic acid (S)-1-benzyl-4,4-dimethyl-pyrrolidin-3-yl ester 

Relevant articles and documents

Novel, potent P2-P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors

Starting from a potent pantolactone ketoamide cathepsin K inhibitor discovered from structural screening, conversion of the lactone scaffold to a pyrrolidine scaffold allowed exploration of the S3 subsite of cathepsin K. Manipulation of P3