881-86-7Relevant articles and documents
Carboxyl Methyltransferase Catalysed Formation of Mono- and Dimethyl Esters under Aqueous Conditions: Application in Cascade Biocatalysis
Ashbrook, Chloe,Carnell, Andrew J.,Goulding, Ellie,Hatton, Harry,Johnson, James R.,Kershaw, Neil M.,McCue, Hannah V.,Rigden, Daniel J.,Ward, Lucy C.
supporting information, (2022/02/21)
Carboxyl methyltransferase (CMT) enzymes catalyse the biomethylation of carboxylic acids under aqueous conditions and have potential for use in synthetic enzyme cascades. Herein we report that the enzyme FtpM from Aspergillus fumigatus can methylate a broad range of aromatic mono- and dicarboxylic acids in good to excellent conversions. The enzyme shows high regioselectivity on its natural substrate fumaryl-l-tyrosine, trans, trans-muconic acid and a number of the dicarboxylic acids tested. Dicarboxylic acids are generally better substrates than monocarboxylic acids, although some substituents are able to compensate for the absence of a second acid group. For dicarboxylic acids, the second methylation shows strong pH dependency with an optimum at pH 5.5–6. Potential for application in industrial biotechnology was demonstrated in a cascade for the production of a bioplastics precursor (FDME) from bioderived 5-hydroxymethylfurfural (HMF).
A cationic Zr-based metal organic framework with enhanced acidic resistance for selective and efficient removal of CrO42-
Jiang, Chao,Sun, Ruopei,Du, Ziyao,Singh, Vikramjeet,Chen, Suwen
, p. 12646 - 12653 (2020/10/13)
Water pollution caused by CrO42- has become a global concern due to its high aqueous solubility and good mobility in the underground environment. Recently, water stable zirconium based metal-organic frameworks (Zr-MOFs) have been tested as adsorbents to remove pollutants from contaminated water. However, the low adsorption capacity of Zr-MOFs towards ionic pollutants is unsatisfactory due to their neutral nature. Herein, a cationic Zr-MOF (Zr-C-MOF) was obtained by directly introducing a pyridinium salt as a ligand with an impressive ion exchange capability. Zr-C-MOF demonstrated enhanced acidic resistance and selectively high adsorption of CrO42-. The characteristics of the obtained Zr-C-MOF were confirmed via various techniques including PXRD, FT-IR spectroscopy, 1H-NMR spectroscopy, TGA, SEM, EDX and XPS. Batch adsorption studies have been conducted to gain a deep understanding of the kinetics mechanism, pH effects, adsorption isotherm and the effects of other competing ions. The kinetics and adsorption isotherm of CrO42- adsorption onto Zr-C-MOF were found to well fit the pseudo-second-order rate equation and the Langmuir model, respectively. The comparison of FT-IR, PXRD, SEM, EDX and XPS results of the samples before and after CrO42- adsorption revealed the adsorption mechanism of the anion exchange process. This journal is
New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action
Ohui, Kateryna,Afanasenko, Eleonora,Bacher, Felix,Ting, Rachel Lim Xue,Zafar, Ayesha,Blanco-Cabra, Núria,Torrents, Eduard,D?m?t?r, Orsolya,May, Nóra V.,Darvasiova, Denisa,Enyedy, éva A.,Popovi?-Bijeli?, Ana,Reynisson, Jóhannes,Rapta, Peter,Babak, Maria V.,Pastorin, Giorgia,Arion, Vladimir B.
supporting information, p. 512 - 530 (2019/01/04)
Six morpholine-(iso)thiosemicarbazone hybrids HL1-HL6 and their Cu(II) complexes with good-to-moderate solubility and stability in water were synthesized and characterized. Cu(II) complexes [Cu(L1-6)Cl] (1-6) formed weak dimeric associates in the solid state, which did not remain intact in solution as evidenced by ESI-MS. The lead proligands and Cu(II) complexes displayed higher antiproliferative activity in cancer cells than triapine. In addition, complexes 2-5 were found to specifically inhibit the growth of Gram-positive bacteria Staphylococcus aureus with MIC50 values at 2-5 μg/mL. Insights into the processes controlling intracellular accumulation and mechanism of action were investigated for 2 and 5, including the role of ribonucleotide reductase (RNR) inhibition, endoplasmic reticulum stress induction, and regulation of other cancer signaling pathways. Their ability to moderately inhibit R2 RNR protein in the presence of dithiothreitol is likely related to Fe chelating properties of the proligands liberated upon reduction.
