88110-86-5

Basic information

• Product Name: 9H-Purin-6-amine, 9-[[(2-hydroxy-2-oxido-1,3,2-dioxaphosphorinan-5-yl)oxy]methyl]-
• Synonyms: 9H-Purin-6-amine, 9-(((2-hydroxy-2-oxido-1,3,2-dioxaphosphorinan-5-yl)oxy)methyl)-
• CAS NO: 88110-86-5
• Molecular Formula: C₉H₁₂N₅O₅P
• Molecular Weight: 799.926
• Mol File: 88110-86-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 576.7°Cat760mmHg
• Flash Point: 302.6°C
• Density: 2.03g/cm³
• CAS DataBase Reference: 9H-Purin-6-amine, 9-[[(2-hydroxy-2-oxido-1,3,2-dioxaphosphorinan-5-yl)oxy]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-Purin-6-amine, 9-[[(2-hydroxy-2-oxido-1,3,2-dioxaphosphorinan-5-yl)oxy]methyl]-(88110-86-5)
• EPA Substance Registry System: 9H-Purin-6-amine, 9-[[(2-hydroxy-2-oxido-1,3,2-dioxaphosphorinan-5-yl)oxy]methyl]-(88110-86-5)

Safety Data

• Hazardous Substances Data: 88110-86-5(Hazardous Substances Data)

Upstream product

• 82410-32-0 ganciclovir 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 18602-85-2 2,6,9-tris(trimethylsilyl)guanine 
• 82410-31-9 9-<<2-(benzyloxy)-1-<(benzyloxy)methyl>ethoxy>methyl>guanine 
• 73-40-5 2-amino-1,9-dihydro-6H-purin-6-one 

Downstream Products

• 109082-86-2 Adamantane-1-carboxylic acid 3-[(4-methoxy-phenyl)-diphenyl-methoxy]-2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-propyl ester 
• 103024-80-2 N²-(p-anisyldiphenylmethyl)-9-<<(p-anisyldiphenylmethoxy)-3-(p-toluenesulfonyloxy)-2-propoxy>methyl>-guanine 
• 269716-58-7 N²-(p-anisyldiphenylmethyl)-9-[[1-(p-anisyldiphenylmethoxy)-3-fluoro-2-propoxy]methyl]guanine 
• 100683-70-3 N²-(p-anisyldiphenylmethyl)-9-<<4-(p-anisyldiphenylmethoxy)-1--3-butoxy>methyl>guanine 
• 100701-09-5 N²-(p-anisyldiphenylmethyl)-9-<<<4-(p-anisyldiphenylmethoxy)-1(E)-(diphenoxyphosphinyl)but-1-en-3-yl>oxy>-methyl>guanine 
• 100701-10-8 N²-(p-anisyldiphenylmethyl)-9-<<4-(p-anisyldiphenylmethoxy)-1-(diphenoxyphosphinyl)-3-butoxy>-methyl>guanine 
• 103024-81-3 N²-(p-anisyldiphenylmethyl)-9-<<1-(p-anisyldiphenylmethoxy)-3-azido-2-propoxy>methyl>guanine 
• 103067-94-3 9-<<3-amino-1-(p-anisyldiphenylmethoxy)-2-propoxy>methyl>-N²-(p-anisyldiphenylmethyl)guanine 
• 100683-71-4 9-<<1--4-hydroxy-3-butoxy>-methyl>guanine 
• 104880-60-6 3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4-hydroxybutylphosphonic acid 
• 109082-87-3 Hexadecanoic acid 3-[(4-methoxy-phenyl)-diphenyl-methoxy]-2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-propyl ester 
• 100683-69-0 3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-propionaldehyde 

Relevant articles and documents

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An Improved Total Synthesis of PET HSV-tk Gene Expression Imaging Agent 9-[(3-[18F]Fluoro-1-hydroxy-2-propoxy)methyl]guanine ([ 18F]FHPG)

An improved total synthesis of [18F]FHPG starting from 1,3-dibenzyloxy-2-propanol and guanine has been developed. [18F]FHPG was prepared by nucleophilic substitution of the appropriate precursor with [18F]KF/ Kryptofix 2.2.2 followed by a quick deprotection reaction and purification with a simplified Silica Sep-Pak solid-phase extraction (SPE) method in 10-15% radiochemical yield, and 70 min synthesis time from end of bombardment (EOB).

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Positron emission tomography (PET) herpes simplex virus thymidine kinase (HSV-tk) gene reporter probes 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy) methyl]guanine ([18F]FHPG) and 9-(4-[18F]fluoro-3- hydroxymethylbutyl)guanine ([18F]FHBG) were prepared by nucleophilic substitution of the appropriate tosylated precursors with [18F]KF/ Kryptofix 2.2.2 followed by a quick deprotection reaction and purification with a simplified dual Silica Sep-Pak solid-phase extraction (SPE) method in 15-30% radiochemical yield.