885-75-6

Basic information

• Product Name: 2-amino-1,2-diphenylethanone
• Synonyms: 2-Amino-2-phenylacetophenone; Acetophenone, 2-amino-2-phenyl-; Desylamine; Ethanone, 2-amino-1,2-diphenyl-
• CAS NO: 885-75-6
• Molecular Formula: C₁₄H₁₃NO*ClH
• Molecular Weight: 211.2591
• Mol File: 885-75-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 363.6°C at 760 mmHg
• Flash Point: 173.7°C
• Density: 1.135g/cm³
• Vapor Pressure: 1.79E-05mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: 2-amino-1,2-diphenylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-1,2-diphenylethanone(885-75-6)
• EPA Substance Registry System: 2-amino-1,2-diphenylethanone(885-75-6)

Safety Data

• Hazardous Substances Data: 885-75-6(Hazardous Substances Data)

Usage

Main properties

1. Chemical compound
2. Molecular formula: C14H13NO
3. Aromatic and carbonyl functional groups
4. Used in organic synthesis and pharmaceutical research

Specific content

1. Reagent in organic synthesis and pharmaceutical research
2. Known for aromatic and carbonyl functional groups
3. Studied for potential biological and pharmacological properties
4. Investigated for potential application in drug development
5. Demonstrated potential as an intermediate in the synthesis of various organic compounds

Upstream product

• 109-06-8 α-picoline 
• 14257-84-2 N-acetyl-α-phenylglycine 
• 93-97-0 benzoic acid anhydride 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 451-40-1 phenyl benzyl ketone 
• 100-58-3 phenylmagnesium bromide 
• 1484-50-0 desyl bromide 
• 904922-22-1 4,5-dimethyl-2-(phenyl-trimethylsilanyloxy-methyl)-thiazole 
• 100-52-7 benzaldehyde 
• 98837-46-8 N-benzylidenediphenylphosphinamide 
• 5908-41-8 benzoyltrimethylsilane 
• 169899-58-5 2-(1-hydroxy-1-phenylmethyl)-4,5-dimethylthiazole 
• 801219-76-1 2-(diphenylphosphinamide)-1,2-diphenylethanone 
• 32493-66-6 2-(2-oxo-1,2-diphenylethyl)isoindoline-1,3-dione 

Downstream Products

• 530-36-9 erythro-2-amino-1,2-diphenylethanol 
• 530-36-9 threo-1,2-diphenyl-2-aminoethan-1-ol 
• 668-94-0 4,5-diphenyl-1H-imidazole 
• 102474-68-0 (1Ξ,2S)-2-amino-1,2-diphenyl-1-p-tolyl-ethanol 
• 65996-43-2 N₁-(1-methyl-2-oxo-2-phenylethyl)-4-methyl-1-benzenesulfonamide 
• 1826-15-9 4,5-diphenylthiazole 
• 200802-52-4 2-(2-nitrophenyl)-4,5-diphenyloxazole 
• 573-34-2 2,4,5-triphenyloxazole 
• 5866-68-2 2-(4-nitrophenyl)-4,5-diphenyloxazole 

Relevant articles and documents

Asymmetric Transfer Hydrogenation: Dynamic Kinetic Resolution of α-Amino Ketones

A series of α-amino ketones were reduced using asymmetric transfer hydrogenation (ATH) through a dynamic kinetic resolution (DKR). The protecting group was matched to the reducing agent, and following optimization, a series of substrates were investigated, giving products in high diastereoselectivity, over 99% ee in several cases and full conversion. The methodology was applied to the enantioselective synthesis of an MDM2-p53 inhibitor precursor.

Concise synthesis of 1H-pyrazin-2-ones and 2-aminopyrazines

Convenient syntheses of 1H-pyrazin-2-ones and 2-aminopyrazines are described. By coupling Boc-protected amino acids with α-amino ketones or with amino alcohols and subsequent oxidation, 1H-pyrazin-2-ones were obtained. Transformation into the corresponding pyrazine triflates and substitution with primary or secondary amines led to 2-aminopyrazines. Since these syntheses take advantage of the use of readily available starting materials (e.g., amino acids, aminoalcohols and amines) a variety of the entitled structures can be obtained in few, high yielding steps.

Pyrrolomorphinans as δ opioid receptor antagonists. The role of steric hindrance in conferring selectivity

A series of 2',3'-disubstituted pyrrolomorphinans (5a-i) were synthesized to determine the role of steric hindrance at μ and γ receptors in promoting δ opioid receptor antagonist selectivity. In smooth muscle preparations, five members of the series (5a-c,e,f) possessed K(e) values in the range 2-15 nM and were 6 selective. Since the unsubstituted analogue 4 possessed δ antagonist potency of similar magnitude, but was not δ selective, it is suggested that the 2',3'substitution confers δ selectivity by hindering the interaction of the pharmacophore at μ and γ receptors, while not affecting δ receptors.