887583-52-0

Basic information

• Product Name: 6-(trifluoromethyl)pyridine-2-carbonitrile
• Synonyms: 6-(trifluoromethyl)pyridine-2-carbonitrile;6-(trifluoromethyl)picolinonitrile;6-(TrifluoroMethyl)-2-pyridinecarbonitrile;2-Pyridinecarbonitrile, 6-(trifluoromethyl)-
• CAS NO: 887583-52-0
• Molecular Formula: C₇H₃F₃N₂
• Molecular Weight: 172.11
• Mol File: 887583-52-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 208.6°C at 760 mmHg
• Flash Point: 80°C
• Appearance: /
• Density: 1.37g/cm³
• Vapor Pressure: 0.212mmHg at 25°C
• Refractive Index: 1.456
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -5.00±0.12(Predicted)
• CAS DataBase Reference: 6-(trifluoromethyl)pyridine-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(trifluoromethyl)pyridine-2-carbonitrile(887583-52-0)
• EPA Substance Registry System: 6-(trifluoromethyl)pyridine-2-carbonitrile(887583-52-0)

Safety Data

• Hazardous Substances Data: 887583-52-0(Hazardous Substances Data)

Usage

General Description

6-(Trifluoromethyl)pyridine-2-carbonitrile is an organic compound with the chemical formula C7H2F3N. It is a pyridine derivative with a trifluoromethyl group (-CF3) and a carbonitrile group (-C≡N) attached to the second carbon atom of the pyridine ring. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is a colorless liquid with a high boiling point and low water solubility, making it suitable for use in organic synthesis reactions. The trifluoromethyl group enhances the chemical's stability, while the carbonitrile group provides reactivity and versatility for further functionalization in various chemical processes.

InChI:InChI=1/C7H3F3N2/c8-7(9,10)6-3-1-2-5(4-11)12-6/h1-3H

Upstream product

• 122918-25-6 6-bromopyridin-2-carbonitrile 
• 189278-27-1 2-bromo-6-(trifluoromethyl)pyridine 

Downstream Products

• 131747-42-7 6-(trifluoromethyl)pyridine-2-carboxylic acid 
• 155377-05-2 6-(trifluoromethyl)pyridine-2-carboxylic acid methyl ester 
• 1446507-38-5 6-(6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4-(1H,3H)-dione 
• 1446507-40-9 2,4-dichloro-6-(6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine 
• 1446507-68-1 4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoro-methyl)-pyridin-4-yl)-1,3,5-triazin-2-amine 
• 1446502-11-9 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol 
• 1269626-16-5 5-(2-Fluoro-benzyl)-2-(6-trifluoromethyl-pyridin-2-yl)-pyrimidine-4,6-diamine 

Relevant articles and documents

Compound with IDH mutant inhibitory activity, preparation method and application thereof

The invention belongs to the field of medicines, and particularly relates to a s-triazine compound with structural characteristics of a general formula I or a pharmaceutically acceptable salt thereof,a pharmaceutical composition and a preparation method thereof, and application of the s-triazine compound or the pharmaceutically acceptable salt and the pharmaceutical composition in preparation ofIDH2 mutant inhibitors. According to the invention, pharmacological experiment results show that the compound disclosed by the invention has an obvious inhibition effect on the activity of an IDH2 mutant (mIDH2), can effectively inhibit the process that alpha-ketoglutaric acid is catalyzed by mIDH2 to generate 2-hydroxyglutaric acid, and can be used for preparing drugs for preventing and/or treating various related diseases caused by IDH2 mutation, wherein the diseases comprise cancers carrying IDH2 mutation.

Copper-mediated perfluoroalkylation of heteroaryl bromides with (phen)CuRF

The attachment of perfluoroalkyl groups onto organic compounds has been a major synthetic goal over the past several decades. Previously, our group reported phenanthroline-ligated perfluoroalkyl copper reagents, (phen)CuR F, which react with aryl iodides and aryl boronates to form the corresponding benzotrifluorides. Herein the perfluoroalkylation of a series of heteroaryl bromides with (phen)CuCF3 and (phen)CuCF 2CF3 is reported. The mild reaction conditions allow the process to tolerate many common functional groups. Perfluoroethylation with (phen)CuCF2CF3 occurs in somewhat higher yields than trifluoromethylation with (phen)CuCF3, creating a method to generate fluoroalkyl heteroarenes that are less accessible from trifluoroacetic acid derivatives.

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