88931-75-3Relevant articles and documents
Substituted 1-benzylcycloalkylcarboxylic acids and the use thereof
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Page/Page column 27-28, (2012/07/14)
The present application relates to novel substituted 1-benzylcycloalkylcarboxylic acid derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
Identification of potent and novel small-Molecule inhibitors of caspase-3
Allen, Darin A.,Pham, Phuongly,Choong, Ingrid C.,Fahr, Bruce,Burdett, Matthew T.,Lew, Willard,DeLano, Warren L.,Gordon, Eric M.,Lam, Joni W.,O'Brien, Tom,Lee, Dennis
, p. 3651 - 3655 (2007/10/03)
The design and synthesis of a series of novel, reversible, small molecule inhibitors of caspase-3 are described.
Conjugate Addition Reactions Mediated by Samarium(II) Iodide
Molander, Gary A.,Harris, Christina R.
, p. 7418 - 7429 (2007/10/03)
Samarium(II) iodide in conjunction with a catalytic low-valent transition metal species has been employed to promote the conjugate addition reaction of primary and secondary alkyl halides onto α,β-unsaturated esters and amides. The method has been determined to be quite general and hence has been extended to the cyclization reactions of alkyl halides onto α,β-unsaturated lactones, lactams, and nitriles. The cyclization reactions described herein provide a very general approach to the synthesis of functionalized carbocycles from simple acyclic precursors with excellent diastereoselectivity and under very mild reaction conditions.
Metal-Halogen Exchange-Initiated Intramolecular Conjugate Addition Reactions of Unsaturated Esters
Cooke, Manning P.
, p. 1144 - 1146 (2007/10/02)
Intramolecular conjugate addition reactions of internal unstabilized nucleophilic centers formed through rapid lithium-halogen exchange reactions have been used to generate carbocycles from ω-iodo-α,β-unsaturated esters.
