89-61-2

Basic information

• Product Name: 2,5-Dichloronitrobenzene
• Synonyms: Benzene, 2,5-dichloronitro-;Benzene,1,4-dichloro-2-nitro-;Benzene,1-nitro-2,5-dichloro;NITRO-P-DICHLOROBENZENE;2-NITRO-1,4-DICHLOROBENZENE;2-NITRO-P-DICHLOROBENZENE;2,5-DICHLORO-1-NITROBENZENE;2,5-DICHLORONITROBENZENE
• CAS NO: 89-61-2
• Molecular Formula: C₆H₃Cl₂NO₂
• Molecular Weight: 192
• EINECS: 201-923-3
• Product Categories: Intermediates of Dyes and Pigments;Aromatic Halides (substituted);Benzene derivates;Dyestuff Intermediates
• Mol File: 89-61-2.mol
• Article Data: 21

Chemical Properties

• Melting Point: 52-54 °C(lit.)
• Boiling Point: 267 °C
• Flash Point: >230 °F
• Appearance: yellow flakes
• Density: 1,442 g/cm3
• Vapor Density: 6.6 (vs air)
• Vapor Pressure: <0.1 mm Hg ( 25 °C)
• Refractive Index: 1.4390 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: 0.083g/l
• Explosive Limit: 2.4-8.5%(V)
• Water Solubility: Soluble in water, ethanol, ether, benzene, carbon disulfide. Slightly soluble in carbon tetrachloride.
• BRN: 778109
• CAS DataBase Reference: 2,5-Dichloronitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Dichloronitrobenzene(89-61-2)
• EPA Substance Registry System: 2,5-Dichloronitrobenzene(89-61-2)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-36-51/53
• Safety Statements: 26-60
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 2
• RTECS: CZ5260000
• TSCA: Yes
• HazardClass: 9
• PackingGroup: III
• Hazardous Substances Data: 89-61-2(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 89-61-2 differently. You can refer to the following data:
1. 2,5-Dichloronitrobenzene is a reagent used in the synthesis of antitrypanosomal, antileishmanial and antimalarial agents. Also it is used in the synthesis of lysophosphatidic acid acyltransferase-β in hibitors.
2. 2,5-Dichloronitrobenzene is a reagent used in the synthesis of antitrypanosomal, antileishmanial and antimalarial agents. Also it is used in the synthesis of lysophosphatidic acid acyltransferase-β inhibitors.

Purification Methods

Crystallise the nitrobenzene from absolute EtOH. [Beilstein 5 IV 726.]

InChI:InChI=1/C6H3Cl2NO2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3H

Synthetic route

2,5 dichloroaniline (95-82-9) → 2,5-dichloronitrobenzene (89-61-2)

Conditions	Yield
With fluoro alcohol In water; ethyl acetate; acetonitrile at -20℃; for 0.0833333h;	97%

para-dichlorobenzene (106-46-7) → 2,5-dichloronitrobenzene (89-61-2)

Conditions	Yield
With ortho-difluorobenzene; sulfuric acid; nitric acid at 35℃; Temperature;	96.7%
With sulfuric acid; nitric acid at 0 - 23℃; for 0.283333h; Inert atmosphere;	93%
With nitric acid

4-chloro-2-nitro-benzoic acid (6280-88-2) → 2,5-dichloronitrobenzene (89-61-2)

Conditions	Yield
With copper(l) iodide; oxygen; copper(l) chloride In dimethyl sulfoxide at 160℃; under 760.051 Torr; for 30h; Schlenk technique; Sealed tube;	78%
With 2.9-dimethyl-1,10-phenanthroline; oxygen; copper (I) acetate; silver sulfate; sodium chloride In dimethyl sulfoxide at 160℃; for 24h; Schlenk technique;	54%
With 2.9-dimethyl-1,10-phenanthroline; oxygen; copper diacetate; silver sulfate; sodium chloride In dimethyl sulfoxide at 160℃; under 760.051 Torr; for 20h; Schlenk technique;	54%

2-nitro-4-chlorobenzenediazonium cation (27165-22-6) → 4,4'-dichloro-2,2'-dinitrobiphenyl (56978-50-8) + 2,5-dichloronitrobenzene (89-61-2)

Conditions	Yield
With hydrogenchloride; copper dichloride

3,6-dichloro-2-nitro-benzaldehyde (10203-04-0) → 2,5-dichloronitrobenzene (89-61-2)

Conditions	Yield
With potassium hydroxide at 100℃;

3,4-dinitroaniline (610-41-3) → 2,5-dichloronitrobenzene (89-61-2)

Conditions	Yield
With hydrogenchloride; acetic acid at 40℃; anschliessendes Behandeln mit Kupfer(I)-chlorid und konz. wss. Salzsaeure bei 70grad;

nitrobenzene (98-95-3) → 2,5-dichloronitrobenzene (89-61-2)

Conditions	Yield
With antimonypentachloride beim Chlorieren;

2-Chloronitrobenzene (88-73-3) → 2,5-dichloronitrobenzene (89-61-2)

Conditions	Yield
With antimonypentachloride bei der Chlorierung;

3-Chloronitrobenzene (121-73-3) → 3,4-dichloronitrobenzene (99-54-7) + 1,2-Dichloro-3-nitrobenzene (3209-22-1) + 2,5-dichloronitrobenzene (89-61-2)

Conditions	Yield
With chlorine; iron(III) chloride at 90℃; Product distribution; relative rates;

nitrobenzene (98-95-3) → 3,4-dichloronitrobenzene (99-54-7) + 3-Chloronitrobenzene (121-73-3) + 1,2-Dichloro-3-nitrobenzene (3209-22-1) + 4-chlorobenzonitrile (100-00-5) + 2-Chloronitrobenzene (88-73-3) + 2,5-dichloronitrobenzene (89-61-2)

Conditions	Yield
With chlorine; iron(III) chloride at 60 - 120℃; Product distribution; Kinetics; relative rates of each steps;

2-Chloronitrobenzene (88-73-3) → 1,2-Dichloro-3-nitrobenzene (3209-22-1) + 1-chloro-2,6-dinitrobenzene (606-21-3) + 1-chloro-2,4-dinitro-benzene (97-00-7) + 2,5-dichloronitrobenzene (89-61-2)

Conditions	Yield
With hydrogenchloride; sulfuric acid; nitric acid at 25℃; Product distribution;	A 0.2 % Chromat. B 6.7 % Chromat. C 94.8 % Chromat. D 0.3 % Chromat.

2-Chloronitrobenzene (88-73-3) → 1,2-Dichloro-3-nitrobenzene (3209-22-1) + 2,5-dichloronitrobenzene (89-61-2)

Conditions	Yield
With chlorine; iron(III) chloride at 90℃; Product distribution; relative rates;

para-dichlorobenzene (106-46-7) → 2,5-dichloronitrobenzene (89-61-2) + 1,2,4-Trichlorobenzene (120-82-1)

Conditions	Yield
With antimonypentachloride; Nitryl chloride In dichloromethane at 20℃; for 0.25h;	A 96 % Chromat. B 4 % Chromat.

chlorine (7782-50-5) + iron(III) chloride (7705-08-0) + nitrobenzene (98-95-3) → 2,5-dichloronitrobenzene (89-61-2)

Conditions	Yield
at 20℃;

chlorine (7782-50-5) + iron(III) chloride (7705-08-0) + nitrobenzene (98-95-3) → 3-Chloronitrobenzene (121-73-3) + 2,5-dichloronitrobenzene (89-61-2)

Conditions	Yield
at 40 - 42℃;

chlorine (7782-50-5) + iron(III) chloride (7705-08-0) + nitrobenzene (98-95-3) → 3-Chloronitrobenzene (121-73-3) + hexachlorobenzene (118-74-1) + 2,5-dichloronitrobenzene (89-61-2)

antimonypentachloride (7647-18-9) + 2-Chloronitrobenzene (88-73-3) → 2,4-dichloronitrobenzene (611-06-3) + 2,5-dichloronitrobenzene (89-61-2) + 2.3-dichloro-1-nitrobenzene

Conditions	Yield
at 100℃; durch Chlorierung;

antimony(III) chloride (10025-91-9) + chlorine (7782-50-5) + nitrobenzene (98-95-3) → 2-Chloronitrobenzene (88-73-3) + 2,5-dichloronitrobenzene (89-61-2)

antimony(III) chloride (10025-91-9) + chlorine (7782-50-5) + nitrobenzene (98-95-3) → 1,2-Dichloro-3-nitrobenzene (3209-22-1) + 2-Chloronitrobenzene (88-73-3) + 2,5-dichloronitrobenzene (89-61-2)

4-Chloro-3-nitroaniline (635-22-3) + sulfuric acid (7664-93-9) → 2,5-dichloronitrobenzene (89-61-2) + 4.4'-dichloro-3.3'-dinitro-diphenyl

Conditions	Yield
at 0℃; Diazotieren und Behandeln mit Kupfer(I)-chlorid und konz.Salzsaeure;

3-Chloronitrobenzene (121-73-3) + antimony chloride → 1,2-Dichloro-3-nitrobenzene (3209-22-1) + 2,5-dichloronitrobenzene (89-61-2)

Conditions	Yield
bei der Chlorierung;

3,6-dichloro-2-nitro-benzaldehyde (10203-04-0) + aqueous KOH-solution → formic acid (64-18-6) + 2,5-dichloronitrobenzene (89-61-2)

3-chloro-4-nitroaniline (825-41-2) → 2,5-dichloronitrobenzene (89-61-2)

Conditions	Yield
Multi-step reaction with 2 steps 1: nitrous acid; alcohol 2: antimony chloride / bei der Chlorierung View Scheme

3-Chloroacetanilide (588-07-8) → 2,5-dichloronitrobenzene (89-61-2)

Conditions	Yield
Multi-step reaction with 3 steps 1: concentrated sulfuric acid; nitric acid / man erhitzt mit Ammoniak im geschlossenen Rohr auf 160grad und trennt die beiden entstandenen Chlor-nitro-aniline durch Destillation mit Wasserdampf 2: nitrous acid; alcohol 3: antimony chloride / bei der Chlorierung View Scheme

benzene (71-43-2) → 2,5-dichloronitrobenzene (89-61-2)

Conditions	Yield
Multi-step reaction with 2 steps 1: iodine; chlorine 2: bei der Nitrierung View Scheme

nitrobenzene (98-95-3) → 3,4-dichloronitrobenzene (99-54-7) + 3-Chloronitrobenzene (121-73-3) + 2,5-dichloronitrobenzene (89-61-2)

Conditions	Yield
With trichloroisocyanuric acid at 200℃; for 5h; Inert atmosphere;

(R,S)-1-(4-chloro-2-nitrophenyl)ethanol (787633-79-8) → 2,5-dichloronitrobenzene (89-61-2)

Conditions	Yield
With 1,10-Phenanthroline; oxygen; potassium carbonate; copper dichloride; silver(l) oxide In dimethyl sulfoxide at 140℃; under 3750.38 Torr; for 36h; Autoclave;	80 %Chromat.

4'-chloro-2'-nitroacetophenone (23082-51-1) → 2,5-dichloronitrobenzene (89-61-2)

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium tetrahydroborate / methanol / 0 °C 2: potassium carbonate; copper dichloride; 1,10-Phenanthroline; oxygen; silver(l) oxide / dimethyl sulfoxide / 36 h / 140 °C / 3750.38 Torr / Autoclave View Scheme

morpholine (110-91-8) + 2,5-dichloronitrobenzene (89-61-2) → 4-(4-chloro-2-nitro-phenyl)morpholine (65976-60-5)

Conditions	Yield
In tetrahydrofuran at 50℃; under 4500360 Torr; for 20h;	100%
at 2℃; Heating;	50%

2,5-dichloronitrobenzene (89-61-2) → 2,5 dichloroaniline (95-82-9)

Conditions	Yield
With hydrogen; zinc dibromide; palladium on activated charcoal In ethyl acetate under 760 Torr;	100%
	99%
With platinum on activated charcoal; hydrogen at 60℃; for 1h; Temperature; Inert atmosphere; Autoclave; Supercritical conditions;	99.4%

2,5-dichloronitrobenzene (89-61-2) → 2-Chloronitrobenzene (88-73-3)

Conditions	Yield
With ammonia at 125℃; under 15001.5 Torr; for 1h; Autoclave;	99.85%

4-chloro-phenol (106-48-9) + 2,5-dichloronitrobenzene (89-61-2) → 4-chloro-1-(4-chlorophenoxy)-2-nitrobenzene (135-12-6)

Conditions	Yield
With potassium hydroxide at 135 - 140℃; for 3.5h; Reagent/catalyst; Temperature; Large scale;	99.53%
With potassium hydroxide In water at 170℃; for 2.5h; Inert atmosphere;	97%
Stage #1: 4-chloro-phenol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.666667h; Stage #2: 2,5-dichloronitrobenzene In N,N-dimethyl-formamide; mineral oil at 80℃; for 1.25h;	93%
With sodium hydride In N,N-dimethyl-formamide at 20℃;

diethylamine (109-89-7) + 2,5-dichloronitrobenzene (89-61-2) → N-(4-Chloro-2-nitrophenyl)diethylamine (86309-90-2)

Conditions	Yield
In tetrahydrofuran at 50℃; under 4500360 Torr; for 20h;	98%
With methanol at 150℃; Kinetik der Reaktion bei 85grad und 110grad;

pyrrolidine (123-75-1) + 2,5-dichloronitrobenzene (89-61-2) → 5-chloro-2-(1-pyrrolidinyl)nitrobenzene (41173-36-8)

Conditions	Yield
In tetrahydrofuran at 50℃; under 4500360 Torr; for 20h;	97%
at 2℃; Heating;

ethyl 2-cyanoacetate (105-56-6) + 2,5-dichloronitrobenzene (89-61-2) → ethyl 2-(4-chloro-2-nitrophenyl)-2-cyanoacetate (65547-99-1)

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 100℃;	97%
Stage #1: ethyl 2-cyanoacetate With sodium hydride; dimethyl sulfoxide In mineral oil for 0.166667h; Stage #2: 2,5-dichloronitrobenzene In mineral oil at 20℃; for 1h;	71%
With sodium ethanolate 1.) EtOH, 2.) EtOH, reflux, 12 h; Multistep reaction;

(2-hydroxyethyl)(methyl)amine (109-83-1) + 2,5-dichloronitrobenzene (89-61-2) → 2-(4chloro-N-methyl-2-nitranilino)ethanol (103748-12-5)

Conditions	Yield
In pyridine for 5h; Heating;	97%

piperidine (110-89-4) + 2,5-dichloronitrobenzene (89-61-2) → 1-(4-chloro-2-nitrophenyl)piperidine (33784-44-0)

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; for 18.5h;	96.4%

2,5-dichloronitrobenzene (89-61-2) + phenol (108-95-2) → 4-chloro-2-nitro-1-phenoxybenzene (91-39-4)

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide	96%
In ethyl acetate; N,N-dimethyl-formamide	95%
With sodium hydroxide; tetrabutylammomium bromide In water for 30h; Heating;	81%

methanol (67-56-1) + 2,5-dichloronitrobenzene (89-61-2) → 4-chloro-2-nitroanisole (89-21-4)

Conditions	Yield
With sodium hydroxide at 70℃; for 2h;	95%
With sodium hydroxide; copper chloride; glycerol
With zinc hydroxide at 150 - 160℃;
With sodium carbonate at 155 - 165℃;

2,4-dichlorophenol (120-83-2) + 2,5-dichloronitrobenzene (89-61-2) → 2,4,4'-trichloro-2'-nitrodiphenyl ether (2392-48-5)

Conditions	Yield
Stage #1: 2,4-dichlorophenol With potassium hydroxide In water at 110℃; Stage #2: 2,5-dichloronitrobenzene In water at 150℃;	95%
With potassium hydroxide
With potassium hydroxide In dimethyl sulfoxide at 100℃;
With potassium hydroxide In water at 125 - 130℃; Large scale;	4642.3 g

methyl thiosalicylate (17999-25-6) + 2,5-dichloronitrobenzene (89-61-2) → methyl S-(2-nitro-4-chloromethylphenyl)thiosalicylate

Conditions	Yield
In methanol; sodium hydroxide; water	95%

3-(methylsulfonyl)propan-1-amine monohydrochloride + 2,5-dichloronitrobenzene (89-61-2) → 4-chloro-N-(3-(methylsulfonyl)propyl)-2-nitroaniline

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In ethanol for 14h; Reflux;	94%

thiophenol (108-98-5) + 2,5-dichloronitrobenzene (89-61-2) → 4-chloro-2-nitrophenyl phenyl sulfide (4548-56-5)

Conditions	Yield
With ammonium acetate In ethanol for 48h; Heating;	92%
With sodium hydroxide In ethanol for 1h; Heating;	90%
With caesium carbonate In acetonitrile at 130℃; for 0.133333h; Microwave irradiation;	66%

methyl 4-hydroxylbenzoate (99-76-3) + 2,5-dichloronitrobenzene (89-61-2) → methyl 4-(4-chloro-2-nitrophenoxy)benzoate (943617-66-1)

Conditions	Yield
With sodium carbonate In ethanol Heating / reflux;	92%

2-Mercaptopyridine (2637-34-5) + 2,5-dichloronitrobenzene (89-61-2) → 2-[(4-chloro-2-nitrophenyl)thio]pyridine (126395-05-9)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 150℃; for 0.166667h; Microwave irradiation;	92%
With sodium In methanol at 65℃; for 7h; Inert atmosphere; Reflux; regioselective reaction;	71%

2-Naphthalenethiol (91-60-1) + 2,5-dichloronitrobenzene (89-61-2) → 4-chloro-2-nitro-1-(2-naphthylthio)benzene (1100794-53-3)

Conditions	Yield
With sodium In methanol at 65℃; for 3h; Inert atmosphere; Reflux; regioselective reaction;	92%
With sodium hydroxide In ethanol; water

Thiophene-2-thiol (7774-74-5) + 2,5-dichloronitrobenzene (89-61-2) → 4-chloro-2-nitrophenyl 2-thienyl sulfide

Conditions	Yield
With potassium carbonate In tetrahydrofuran at 40℃; for 0.5h; Microwave irradiation;	92%
With sodium hydroxide In ethanol; water

1-benzyl-2-mercapto-1H-imidazolo-5-carboxylic acid (84345-15-3) + 2,5-dichloronitrobenzene (89-61-2) → 3-Benzyl-2-(4-chloro-2-nitro-phenylsulfanyl)-3H-imidazole-4-carboxylic acid (108403-90-3)

Conditions	Yield
With sodium In ethanol; N,N-dimethyl-formamide for 1.5h; Heating;	90%

1-(2-(piperidin-4-yl)ethyl)piperidine (14759-09-2) + 2,5-dichloronitrobenzene (89-61-2) → 1-(4-chloro-2-nitro-phenyl)-4-(2-piperidin-1-yl-ethyl)-piperidine (1314530-83-0)

Conditions	Yield
In acetonitrile at 175℃; for 0.5h; Microwave irradiation;	90%

ethylamine (75-04-7) + 2,5-dichloronitrobenzene (89-61-2) → N-ethyl-4-chloro-2-nitro-aniline (28491-95-4)

Conditions	Yield
In ethanol	89%
With ethanol at 160℃;
at 2℃; Heating;

2,5-dichloronitrobenzene (89-61-2) → 2-fluoro-5-chloronitrobenzene (345-18-6)

Conditions	Yield
With potassium fluoride; polydiallyldimethylammonium chloride In dimethyl sulfoxide at 200℃; for 1h;	88.6%
With potassium fluoride; bis(tricyclohexylphosphine)nickel(II) dichloride; tetrabutyl ammonium fluoride In N,N-dimethyl-formamide at 150℃; for 8h; Inert atmosphere;	77.2%
With potassium fluoride; tetraphenylphosphonium bromide at 145 - 155℃; for 6h;	56%

tert-Butyl chloroacetate (107-59-5) + 2,5-dichloronitrobenzene (89-61-2) → (2,5-dichloro-4-nitrophenyl)acetic acid tert-butyl ester

Conditions	Yield
With lithium tert-butoxide In ISOPROPYLAMIDE at -5 - 0℃; for 2h; Product distribution / selectivity;	88%
With sodium t-butanolate In ISOPROPYLAMIDE at -5 - 0℃; for 2h; Product distribution / selectivity;	86%

pyridine-4-thiol (4556-23-4) + 2,5-dichloronitrobenzene (89-61-2) → 4-[(4-chloro-2-nitrophenyl)thio]pyridine

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 150℃; for 0.166667h; Microwave irradiation;	88%

1-phenylvinylboronic acid MIDA ester (1311484-52-2) + 2,5-dichloronitrobenzene (89-61-2) → 4-chloro-2-nitro-1-(1-phenylvinyl)benzene

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 120℃; for 0.5h; Suzuki-Miyaura Coupling;	88%

uracil (66-22-8) + 2,5-dichloronitrobenzene (89-61-2) → 1-(4-chloro-2-nitro-phenyl)-1H-pyrimidine-2,4-dione

Conditions	Yield
With zinc(II) oxide at 130℃; for 0.133333h; Ionic liquid; Microwave irradiation;	87%
With silica gel; caesium carbonate In dimethyl sulfoxide for 0.05h; microwave irradiation;	77%
With silica gel; caesium carbonate In dimethyl sulfoxide at 150℃; for 3.33333h;	68%

ethanolamine (141-43-5) + 2,5-dichloronitrobenzene (89-61-2) → 2-(4-chloro-2-nitrophenylamino)ethanol (59320-13-7)

Conditions	Yield
In butan-1-ol Reflux;	86%
With butan-1-ol
With potassium carbonate
With ethanol at 140℃;
at 2℃; Heating;

Upstream product

• 88-73-3 2-Chloronitrobenzene 
• 635-22-3 4-Chloro-3-nitroaniline 
• 7664-93-9 sulfuric acid 
• 121-73-3 3-Nitrochlorobenzene 
• 23082-51-1 4'-chloro-2'-nitroacetophenone 
• 787633-79-8 (R,S)-1-(4-chloro-2-nitrophenyl)ethanol 
• 6280-88-2 4-chloro-2-nitro-benzoic acid 
• 98-95-3 nitrobenzene 
• 71-43-2 benzene 
• 588-07-8 3-Chloroacetanilide 
• 825-41-2 3-chloro-4-nitroaniline 
• 95-82-9 2,5 dichloroaniline 
• 10203-04-0 3,6-dichloro-2-nitro-benzaldehyde 
• 10025-91-9 antimony(III) chloride 

Downstream Products

• 65976-60-5 4-(4-chloro-2-nitro-phenyl)morpholine 
• 13511-03-0 N-(4-chloro-2-nitrophenyl)pyridin-2-amine 
• 667938-09-2 (4-chloro-2-nitro-phenyl)-dibenzofuran-3-yl-amine 
• 32724-91-7 (4-chloro-2-nitro-phenyl)-p-tolyl-amine 
• 24591-15-9 N-(4-chloro-2-nitrophenyl)-N-(4-chlorophenyl)amine 
• 6373-69-9 4-chloro-N-(4-methoxyphenyl)-2-nitro-aniline 
• 59320-13-7 2-(4-chloro-2-nitrophenylamino)ethanol 
• 873420-54-3 N,N'-bis-(4-chloro-2-nitro-phenyl)-ethylenediamine 
• 86309-90-2 N-(4-Chloro-2-nitrophenyl)diethylamine 
• 24102-89-4 N,N-diethyl-N'-(4-chloro-2-nitro-phenyl)-ethylenediamine 
• 16611-15-7 N-(4-chloro-2-nitrophenyl)benzenamine 
• 50437-60-0 (4-chloro-2-nitro-phenyl)-p-tolyl sulfide 
• 32724-89-3 (4-chloro-2-nitro-phenyl)-(3-chloro-phenyl)-amine 
• 15211-88-8 CD₀₅₁₁₅ 

Relevant articles and documents

Electrochemical synthesis of 2,5-dichloroaniline

A procedure was proposed for electrochemical reduction of 2,5-dichloronitrobenzene to 2,5-dichloroaniline in aqueous-ethanolic solution of sulfuric acid. The procedure for preparing 2,5-dichloroanilinium sulfate was optimized. The influence exerted by the cathode material, nature and amount of the organic solvent, sulfuric acid concentration, and electrolysis temperature on the yield and quality of the target product was discussed.

Nitration of aromatics with dinitrogen pentoxide in a liquefied 1,1,1,2-tetrafluoroethane medium

Regardless of the sustainable development path, today, there are highly demanded chemical productions still operating that bear environmental and technological risks inherited from the previous century. The fabrication of nitro compounds, and nitroarenes in particular, is traditionally associated with acidic wastes formed in nitration reactions exploiting mixed acids. However, nitroarenes are indispensable for industrial and military applications. We faced the challenge and developed a greener, safer, and yet effective method for the production of nitroaromatics. The proposed approach comprises the application of an eco-friendly nitrating agent, namely dinitrogen pentoxide (DNP), in the medium of liquefied 1,1,1,2-tetrafluoroethane (TFE) - one of the most non-hazardous Freons. Importantly, the used TFE is not emitted into the atmosphere but is effortlessly recondensed and returned into the process. DNP is obtainedviathe oxidation of dinitrogen tetroxide with ozone. The elaborated method is characterized by high yields of the targeted nitro arenes, mild reaction conditions, and minimal amount of easy-to-utilize wastes.

Preparation method of nitrification organic matter and prepared nitrification organic matter

The invention discloses a preparation method of nitrification organic matter and the prepared nitrification organic matter, and relates to the technical field of organic synthesis. The preparation method of the nitrification organic substance comprises the following steps: introducing a nitrification acid liquid and molten-state organic matter to be nitrified into a microchannel reactor, and performing a reaction, wherein the organic matter to be nitrified is solid at normal temperature, and solidification and/or dissolution in the nitrification acid liquid does not occur in the organic matterto be nitrified after the organic matter to be nitrified is introduced into the microchannel reactor. According to the preparation method of the nitrification organic matter provided by the invention, the nitrification organic matter prepared by the method has a very good yield and purity without a solvent removal post-treatment process; in the whole process, no solvent participates in the reaction, so that the post-treatment process of solvent removal is avoided; and the method has high safety in the whole reaction process, adopts automation control, has high production efficiency and a greatly-improved production environment, and has larger industrial application value.