890655-08-0

Basic information

• Product Name: Cetilistat Intermediate
• Synonyms: Cetilistat Intermediate;2-hexadecyloxycarbonyl-amino-5-methyl-benzoic acid
• CAS NO: 890655-08-0
• Molecular Formula: C₂₅H₄₁NO₄
• Molecular Weight: 419.59734
• Mol File: 890655-08-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 512.5±43.0 °C(Predicted)
• Appearance: /
• Density: 1.035±0.06 g/cm3(Predicted)
• PKA: 3.77±0.36(Predicted)
• CAS DataBase Reference: Cetilistat Intermediate(CAS DataBase Reference)
• NIST Chemistry Reference: Cetilistat Intermediate(890655-08-0)
• EPA Substance Registry System: Cetilistat Intermediate(890655-08-0)

Safety Data

• Hazardous Substances Data: 890655-08-0(Hazardous Substances Data)

Usage

General Description

Cetilistat Intermediate is a chemical compound used in the synthesis of the pharmaceutical drug cetilistat, which is a weight loss medication. It is a key intermediate in the manufacturing process of cetilistat and is essential for its production. Cetilistat works by inhibiting the enzyme lipase, which is responsible for breaking down dietary fat in the intestine. This prevents the absorption of fat and helps in weight loss. Cetilistat Intermediate is a crucial component in the development of this medication and plays a significant role in its effectiveness as a weight management treatment.

Upstream product

• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 1602765-10-5 1-hexadecyloxycarbonylimidazole 
• 36653-82-4 1-Hexadecanol 
• 26272-90-2 cetyl chloroformate 
• 201230-82-2 carbon monoxide 

Downstream Products

• 282526-98-1 2-hexadecyloxy-6-methyl-4-chloro-1-benzoxazin-4-one 

Relevant articles and documents

NOVEL PROCESSES FOR THE PREPARATION OF 2-OXY-BENZOXAZINONE DERIVATIVES

Provided herein are novel, commercially viable and industrially advantageous processes for the preparation of 2-hexadecyloxy-6-methyl-4H-3,1-benzoxazin-4-one, and its intermediates, in high yield and purity.

A he west for favorable department method of preparation

The invention discloses a method for preparing cetilistat, which belongs to the technical field of the medicine preparation method, and is used for solving the problems of high three wastes, low yield and high cost in the current preparation method. The method comprises the following steps: 1)esterifying a compound A(2-amino-5-methyl benzoic acid) or its salt; 2) acylating an esterification object in the step 1) and chloroformic acid n-cetanol ester; 3)removing ester group of the compound obtained in the step 2) to obtain 2-(cetane carbonyl oxygen)amino-5-methyl benzoic acid; and 4)cyclizing the compound in the step 3) to obtain the target products. By improving the production steps, the invention provides the synthetic method with simple operation, high efficiency, and convenient industrial production for the cetilistat product.

One-pot high-yielding preparation of cetilistat

The invention relates to a new process for one-pot preparation of cetilistat; the one-pot reaction is adopted, separation steps are sample, the product yield is high, the product quality is good, and the new process is especially suitable for industrialized production.