89180-45-0

Basic information

• Product Name: 5-Chloro-2-hydroxypyrazine
• Synonyms: 5-Chloropyrazin-2-ol;5-Chloro-2-hydroxypyrazine;2-hydroxy-5-chloropyrazine;5-Chloropyrazin-2-ol, 5-Chloro-2-hydroxy-1,4-diazine;Pyrazinol, 5-chloro-;5-chloro-1H-pyrazin-2-one
• CAS NO: 89180-45-0
• Molecular Formula: C₄H₃ClN₂O
• Molecular Weight: 130.53
• Mol File: 89180-45-0.mol

Chemical Properties

• Melting Point: 138-140 °C
• Boiling Point: 419.6 °C at 760 mmHg
• Flash Point: 207.5 °C
• Appearance: /
• Density: 1.553g/cm³
• Vapor Pressure: 1.23E-07mmHg at 25°C
• Refractive Index: 1.632
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 10.02±0.40(Predicted)
• CAS DataBase Reference: 5-Chloro-2-hydroxypyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-2-hydroxypyrazine(89180-45-0)
• EPA Substance Registry System: 5-Chloro-2-hydroxypyrazine(89180-45-0)

Safety Data

• Hazardous Substances Data: 89180-45-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Chloro-2-hydroxypyrazine is used as a key intermediate in the synthesis of bioactive molecules for pharmaceutical applications. Its unique structure allows for the development of new drugs with potential therapeutic benefits.
Used in Organic Synthesis:
As a building block in organic synthesis, 5-Chloro-2-hydroxypyrazine is utilized for the preparation of a wide range of chemical compounds, contributing to the advancement of chemical research and the creation of novel materials.
Used in Antimicrobial and Antifungal Applications:
5-Chloro-2-hydroxypyrazine has been studied for its potential antimicrobial and antifungal properties, making it a candidate for use in the development of new antimicrobial agents to combat resistant strains of bacteria and fungi.
Used in Material Science:
5-Chloro-2-hydroxypyrazine has been investigated for its role in the development of new materials, owing to its unique chemical structure and properties. 5-Chloro-2-hydroxypyrazine may contribute to the creation of innovative materials with specific characteristics for various applications.
Used in Agrochemical Production:
5-Chloro-2-hydroxypyrazine has been explored as a possible component in the production of agrochemicals, where it could be used to develop new pesticides or other agricultural chemicals to improve crop protection and yield.

InChI:InChI=1/C4H3ClN2O/c5-3-1-7-4(8)2-6-3/h1-2H,(H,7,8)

Upstream product

• 33332-29-5 2-amino-5-chloropyrazine 
• 5049-61-6 2-Aminopyrazine 

Downstream Products

• 19745-07-4 2,5-dichloropyrazine 

Relevant articles and documents

Discovery of pyrimidine nucleoside dual prodrugs and pyrazine nucleosides as novel anti-HCV agents

To explore the application potential of dual prodrug strategies in the development of anti-HCV agents, a variety of sofosbuvir derivatives with modifications at the C4 or N3 position of the uracil moiety were designed and synthesized. Some compounds exhibited potent anti-HCV activities, such as 4e and 8a–8c with similar EC50 values (0.20–0.22 μM) comparative to that of sofosbuvir (EC50 = 0.18 μM) in a genotype 1b based replicon Huh-7 cell line. Moreover, 8b displayed a good human plasma stability profile, and was easily metabolized in human liver microsomes expectantly. On the other hand, aiming to discover novel anti-HCV nucleosides, pyrazin-2(1H)-one nucleosides and their phosphoramidate prodrugs were investigated. Several active compounds were discovered, such as 25e (EC50 = 7.3 μM) and S-29b (EC50 = 19.5 μM). This kind of nucleosides were interesting and would open a new avenue for the development of antiviral agents.

AMIDOPYRAZOLE DERIVATIVE

A platelet coagulation inhibitor which inhibits neither COX-1 nor COX-2 is provided. The inhibitor is a compound represented by general formula (I): wherein Ar1 and Ar2 independently represent a 5- or 6-membered aromatic heterocyclic group optionally substituted with 1 to 3 substituents, or a phenyl group optionally substituted with 1 to 3 substituents; R1 represents a lower acyl group, carboxyl group, a lower alkoxycarbonyl group, a lower alkoxy group, a lower alkyl group optionally substituted with 1 or 2 substituents, a carbamoyl group optionally substituted with 1 or 2 substituents, an oxamoyl group optionally substituted with 1 or 2 substituents, an amino group optionally substituted with 1 or 2 substituents, a 4- to 7-membered alicyclic heterocyclic group optionally substituted with 1 or 2 substituents, a phenyl group optionally substituted with 1 to 3 substituents, or a 5- or 6-membered aromatic heterocyclic group optionally substituted with 1 to 3 substituents; and R2 represents hydrogen atom, a halogeno group, or the like.