89402-43-7

Basic information

• Product Name: 2,3-Difluoro-5-chloropyridine
• Synonyms: 2,3-DIFLUORO-5-CHLOROPYRIDIN;2,3-DIFLUORO-5-CHLOROPYRIDINE;5-CHLORO-2,3-DIFLUOROPYRIDINE;5-Chloro-2,3-Difluoropyridine96%;2,3-Difluoro-5-Chloro;2,3-Difulor-5-Chloropyridine;5-Chloro-2,3-difluoropyridine 98%;5-Chloro-2,3-difluoropyridine98%
• CAS NO: 89402-43-7
• Molecular Formula: C₅H₂ClF₂N
• Molecular Weight: 149.53
• EINECS: 410-090-7
• Product Categories: blocks;FluoroCompounds;Pyridines;Pyridine;Chloropyridines;Fluoropyridines;Halopyridines;Fluorine series;alkyl Fluorine| alkyl chloride
• Mol File: 89402-43-7.mol
• Article Data: 13

Chemical Properties

• Melting Point: 47-49 C
• Boiling Point: 135°C
• Flash Point: 135°C
• Appearance: Clear liquids
• Density: 1,442 g/cm3
• Refractive Index: 1.4738
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: -5.14±0.20(Predicted)
• BRN: 4177319
• CAS DataBase Reference: 2,3-Difluoro-5-chloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Difluoro-5-chloropyridine(89402-43-7)
• EPA Substance Registry System: 2,3-Difluoro-5-chloropyridine(89402-43-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-52/53-10-36/37/38-20/21/22
• Safety Statements: 23-36-61-26
• RIDADR: 2810
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 89402-43-7(Hazardous Substances Data)

Usage

Uses

5-Chloro-2,3-difluoropyridine is a 2,3,5-trihalopyridine used in the preparation of the herbicides and pesticides such as chodinafop-propargyl.

Upstream product

• 16063-70-0 2,3,5-trichloropyridine 
• 23906-97-0 tetra-n-octylphosphonium bromide 
• 103999-77-5 2,5-dichloro-3-fluoropyridine 
• 13400-13-0 cesium fluoride 
• 823-56-3 2-Fluoro-3,5-dichloropyridine 
• 81175-49-7 tetrakis(diethylamino)phosphonium bromide 
• 2751-90-8 tetraphenylphosphonium bromide 
• 78607-32-6 3-amino-2,5-dichloropyridine 
• 75272-53-6 2,4,4-trichloro-4-formylbutyronitrile 

Downstream Products

• 406676-26-4 5-chloro-2,3-difluoro-4-iodopyridine 
• 1609468-30-5 (R)-benzyl 3-(5-acetamido-3-(4-((5-chloro-3-fluoropyridin-2-yl)oxy)phenyl)-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate 
• 1334167-86-0 2-Ethoxy-3-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine 
• 886373-94-0 5-chloro-2-ethoxy-3-fluoro-pyridine 
• 1154579-82-4 2,3-difluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 1227622-70-9 2-benzyloxy-5-chloro-3-fluoro-pyridine 
• 514797-96-7 5-chloro-3-fluoropyridin-2-ol 
• 246847-98-3 5-chloro-3-fluoro-pyridine-2-amine 
• 514798-01-7 2-bromo-5-chloro-3-fluoro-4-pyridinecarboxylic acid 
• 514798-17-5 6-bromo-3-chloro-5-fluoro-2-pyridinecarboxylic acid 
• 514798-20-0 methyl 3-chloro-5-fluoro-6-iodo-2-pyridinecarboxylate 
• 514798-04-0 2,5-dichloro-3-fluoro-4-iodopyridine 
• 207994-08-9 5-chloro-3-fluoro-2-pyridinecarboxylic acid 
• 514798-03-9 3-chloro-5-fluoro-4-pyridinecarboxylic acid 

Relevant articles and documents

A kind of boron-containing compounds and their use in catalytic fluorination reaction (by machine translation)

The invention relates to the field of fine chemical engineering, in particular to boron-containing compounds and application thereof in catalytic fluorination reaction. The boron-containing compoundsprovided by the invention are used as a catalyst and can be fluorinated by further mild reaction. Compared with the prior art, the boron-containing compounds have the advantages of mild conditions andhigh efficiency of the fluorination reaction, novel catalysis principle, simplicity and convenience in operation, less pollution, low solvent cost and suitability for industrial production.

Process for preparing 2-aminopyridine derivatives

A method for preparing 2-aminopyridine derivatives, which comprises substituting of fluorine for hydrazine moiety and reducing with hydrogen using 3-substituted-2,5,6-trifluoropyridine as a starting material, provides 2-aminopyridine derivatives having a purity over 98% under a mild reaction condition.

Process for preparing fluorine-containing compounds

The present invention relates to a process for preparing fluorine-containing compounds by reacting a compound which contains fluorine-exchangeable halogen with a fluoride or a mixture of fluorides with the formula IMeF??(I),in which Me is an alkaline earth metal ion, NH4+-ion or alkali metal ion, in the presence of a compound or a mixture of compounds of the formula (II) in which A1, A2, A3, A4, A5, A6, A7, A8 independently of one another are identical or different and are a straight-chain or branched alkyl or alkenyl having 1 to 12 carbon atoms, cycloalkyl having 4 to 8 carbon atoms, an aryl having 6 to 12 carbon atoms, or an aralkyl having 7 to 12 carbon atoms, or A1 A2, A3A4, A5A6, and A7A8 independently of one another are identical or different and are connected to one another directly or by way of O or N—A9 to form a ring having 3 to 7 ring members, A9 is an alkyl having 1 to 4 carbon atoms and B?is a monovalent acid radical or the equivalent of a polyvalent acid radical, in the presence or absence of a solvent at a temperature from 40 to 260° C.