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89466-59-1

2-Chloro-4-methyl-6-methylsulfanyl-pyrimidine, a pyrimidine derivative with the molecular formula C6H6ClN3S, features a chlorine atom at the 2-position and methyl and methylsulfanyl groups at the 4and 6-positions, respectively. This chemical compound serves as a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and various pyrimidine derivatives for biochemical research. Its potential biological activities, such as antimicrobial and anticancer properties, have also been explored.

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  • 2-Chloro-4-Methyl-6-Methylsulfanyl-Pyrimidine,2-chloro-4-methyl-6-methylsulfanylpyrimidine, MFCD09832937

    Cas No: 89466-59-1

  • USD $ 300.0-500.0 / Gram

  • 1 Gram

  • 10 Kilogram/Month

  • GL Biochem (Shanghai) Ltd.
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  • 89466-59-1 Structure

  • Basic information

    1. Product Name: 2-CHLORO-4-METHYL-6-METHYLSULFANYL-PYRIMIDINE
    2. Synonyms: 2-CHLORO-4-METHYL-6-METHYLSULFANYL-PYRIMIDINE;2-Chloro-4-methylsulfanyl-6-methylpyrimidine;PyriMidine,2-chloro-4-Methyl-6-(Methylthio)-;2-Chloro-4-Methyl-6-(Methylthio)pyriMidine;2-chloro-4-Methylthio-6-methylpyrimidine
    3. CAS NO:89466-59-1
    4. Molecular Formula: C6H7ClN2S
    5. Molecular Weight: 174.65118
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 89466-59-1.mol

  • Chemical Properties

    1. Melting Point: 120-122 °C
    2. Boiling Point: 291.9 °C at 760 mmHg
    3. Flash Point: 130.3 °C
    4. Appearance: /
    5. Density: 1.3 g/cm3
    6. Refractive Index: 1.581
    7. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    8. Solubility: N/A
    9. PKA: 0.27±0.30(Predicted)
    10. CAS DataBase Reference: 2-CHLORO-4-METHYL-6-METHYLSULFANYL-PYRIMIDINE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-CHLORO-4-METHYL-6-METHYLSULFANYL-PYRIMIDINE(89466-59-1)
    12. EPA Substance Registry System: 2-CHLORO-4-METHYL-6-METHYLSULFANYL-PYRIMIDINE(89466-59-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 89466-59-1(Hazardous Substances Data)

89466-59-1 Usage

Uses

Used in Pharmaceutical Synthesis:
2-Chloro-4-methyl-6-methylsulfanyl-pyrimidine is used as a key intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into diverse drug molecules, enhancing their therapeutic properties and targeting specific biological pathways.
Used in Agrochemical Production:
In the agrochemical industry, 2-chloro-4-methyl-6-methylsulfanyl-pyrimidine is utilized as a building block for the development of novel agrochemicals, contributing to the creation of more effective and targeted pest control agents.
Used in Biochemical Research:
2-Chloro-4-methyl-6-methylsulfanyl-pyrimidine is employed as a research compound in biochemical studies, where it serves as a fundamental component in the preparation of various pyrimidine derivatives, aiding in the discovery of new chemical entities with potential applications in medicine and biology.
Used in Antimicrobial Applications:
2-CHLORO-4-METHYL-6-METHYLSULFANYL-PYRIMIDINE has been studied for its antimicrobial properties, making it a candidate for use in applications targeting the inhibition of microbial growth, which can be beneficial in various industries such as healthcare and food preservation.
Used in Anticancer Research:
2-Chloro-4-methyl-6-methylsulfanyl-pyrimidine's potential anticancer properties are being investigated for its use in oncology research, where it may contribute to the development of new therapeutic agents against cancer.

Check Digit Verification of cas no

The CAS Registry Mumber 89466-59-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,4,6 and 6 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 89466-59:
(7*8)+(6*9)+(5*4)+(4*6)+(3*6)+(2*5)+(1*9)=191
191 % 10 = 1
So 89466-59-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H7ClN2S/c1-4-3-5(10-2)9-6(7)8-4/h3H,1-2H3

89466-59-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-chloro-4-methyl-6-methylsulfanylpyrimidine

1.2 Other means of identification

Product number -
Other names 2-Chlor-4-methylmercapto-6-methyl-pyrimidin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:89466-59-1 SDS

89466-59-1Downstream Products

89466-59-1Relevant articles and documents

INHIBITORS OF RET

-

Page/Page column 49, (2017/05/20)

Inhibitors of wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.

POTASSIUM CHANNEL MODULATORS

-

Paragraph 00181; 00182, (2018/01/17)

Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions which can be affected by potassium channel modulation. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with potassium channels.

Regioselective 2-Amination of Polychloropyrimidines

Smith, Sean M.,Buchwald, Stephen L.

supporting information, p. 2180 - 2183 (2016/06/01)

The regioselective amination of substituted di- and trichloropyrimidines affording the 2-substituted products is reported. While aryl- and heteroarylamines require the use of a dialkylbiarylphosphine-derived palladium catalyst for high efficiency, more nucleophilic dialkylamines produce 2-aminopyrimidines under noncatalyzed SNAr conditions. The key is the use of 5-trimethylsilyl-2,4-dichloropyrimidine as a surrogate for the parent dichloropyrimidine. For more challenging cases, the 2-chloro-4-thiomethoxy analogues were prepared and exclusively afford the desired 2-aminated-4-thiomethoxypyrimidine products.

HEPATITIS B VIRAL ASSEMBLY EFFECTORS

-

Paragraph 00178, (2016/10/31)

Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed is a process to synthesize disclosed compounds, method of treatment of HBV by administration of disclosed compounds, and use of these compounds in the manufacture of medicaments against HBV.

HEPATITIS B VIRAL ASSEMBLY EFFECTORS

-

Paragraph 00127, (2015/05/05)

Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed is a process to synthesize disclosed compounds, method of treatment of HBV by administration of disclosed compounds, and use of these compounds in the manufacture of medicaments against HBV.

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