89617-36-7

Basic information

• Product Name: 4-[6-[(3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-2,4-dihydro-1H -tetracen-1-yl)oxy]-3-hydroxy-2-methyl-oxan-4-yl]morpholine-3-carbonit rile
• Synonyms: 4-[6-[(3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-2,4-dihydro-1H -tetracen-1-yl)oxy]-3-hydroxy-2-methyl-oxan-4-yl]morpholine-3-carbonit rile
• CAS NO: 89617-36-7
• Molecular Formula: C32H34N2O11
• Molecular Weight: 0
• Mol File: 89617-36-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 862.2°C at 760 mmHg
• Flash Point: 475.2°C
• Appearance: /
• Density: 1.54g/cm³
• Vapor Pressure: 1.06E-31mmHg at 25°C
• Refractive Index: 1.682
• CAS DataBase Reference: 4-[6-[(3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-2,4-dihydro-1H -tetracen-1-yl)oxy]-3-hydroxy-2-methyl-oxan-4-yl]morpholine-3-carbonit rile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[6-[(3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-2,4-dihydro-1H -tetracen-1-yl)oxy]-3-hydroxy-2-methyl-oxan-4-yl]morpholine-3-carbonit rile(89617-36-7)
• EPA Substance Registry System: 4-[6-[(3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-2,4-dihydro-1H -tetracen-1-yl)oxy]-3-hydroxy-2-methyl-oxan-4-yl]morpholine-3-carbonit rile(89617-36-7)

Safety Data

• Hazardous Substances Data: 89617-36-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C32H34N2O11/c1-14-27(36)19(34-7-8-43-13-16(34)12-33)9-22(44-14)45-21-11-32(41,15(2)35)10-18-24(21)31(40)26-25(29(18)38)28(37)17-5-4-6-20(42-3)23(17)30(26)39/h4-6,14,16,19,21-22,27,36,38,40-41H,7-11,13H2,1-3H3

Upstream product

• 7456-83-9 2,2'-oxybis(acetaldehyde) 
• 23541-50-6 daunomycin hydrochloride 
• 75-05-8 acetonitrile 

Relevant articles and documents

Intensely potent morpholinyl anthracyclines

3'-Deamino-3'-(3-cyano-4-morpholinyl)doxorubicin is a new analogue that is 100 to 1000 times more potent than doxorubicin against tumors in cell culture or in mice, that is active by intraperitoneal, intravenous, or oral dosing, and that does not produce chronic myocardial lesions in mice. This analogue was encountered in studies on the reductive alkylation of doxorubicin and daunorubicin with 2,2'-oxybis[acetaldehyde], which constructs a morpholino ring incorporating the amino N. The morpholinyl nitrile byproducts are separated by virtue of their nonbasicity from the expected morpholino derivatives. The 13-dihydro and 5-imino derivatives are also described in this important new class of anthracyclines.