896867-87-1

Basic information

• Product Name: 1-(o-tolyl)ethan-1-one-O-acetyl oxime
• Synonyms: 1-(o-tolyl)ethan-1-one-O-acetyl oxime
• CAS NO: 896867-87-1
• Molecular Weight: 191.23
• Mol File: 896867-87-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-(o-tolyl)ethan-1-one-O-acetyl oxime(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(o-tolyl)ethan-1-one-O-acetyl oxime(896867-87-1)
• EPA Substance Registry System: 1-(o-tolyl)ethan-1-one-O-acetyl oxime(896867-87-1)

Safety Data

• Hazardous Substances Data: 896867-87-1(Hazardous Substances Data)

Upstream product

• 27810-08-8 1-(2-methylphenyl)ethanone oxime 
• 108-24-7 acetic anhydride 

Downstream Products

• 1462327-94-1 dimethyl 5-(o-tolyl)-1H-pyrrole-2,3-dicarboxylate 
• 52146-06-2 2-(2-methylphenyl)quinoline 
• 1612759-95-1 (Z)-1-(o-tolyl)-2-tosylethenamine 
• 76646-59-8 2-phenyl-6-(o-tolyl)pyridine 

Relevant articles and documents

Synthesis of enaminones via copper-catalyzed decarboxylative coupling reaction under redox-neutral conditions

A novel copper-catalyzed C(sp3)-H oxidative functionalization of aromatic oxime acetates with α-oxocarboxylic acids was reported. This process involved N-O/C-C bond cleavages and C-C bond formations to furnish substituted enaminones under redox-neutral conditions. The oxime acetates served as both reactants and internal oxidants. Furthermore, this transformation also features good functional group tolerance and needs no ligands or additional bases.

Direct access to bis-S-heterocycles via copper-catalyzed three component tandem cyclization using S8 as a sulfur source

A novel strategy for constructing sulfur containing bis-S-heterocyclic compounds from oxime esters/vinyl azide, phenylacetylene/aldehydes and elemental sulfur (S8) has been developed. These transformations show good functional group tolerance. Various bis-S-heterocyclic products were efficiently synthesized from easily prepared or widely commercially available starting materials. In this protocol, S8 successfully served as a two-sulfur atom donor for thiophene and thiazole rings, respectively.

Synthesis of symmetrical pyridines by iron-catalyzed cyclization of ketoxime acetates and aldehydes

A novel and facile iron-catalyzed cyclization of ketoxime acetates and aldehydes for the green synthesis of substituted pyridines has been developed. In the presence of a FeCl3 catalyst, this reaction exhibited a good functional group tolerance to produce 2,4,6-triarylsubstituted symmetrical pyridines in high yields in the absence of any additive. A gram-scale reaction sequence was performed to demonstrate the scaled-up applicability of this synthetic method.