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ACETYLNEURAMINYL HYDROLASE, also known as neuraminidase, is a hydrolytic enzyme that cleaves sialic acid residues from glycoproteins and glycolipids. It is capable of removing various types of sialic acid, including N-acetylneuraminic and N-glycolylneuraminic acid, through hydrolysis of different linkages such as α(2→6), α(2→3), α(2→8), and α(2→9). The enzyme plays a crucial role in the study and characterization of glycoproteins, as well as in various applications across different industries.

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  • 9001-67-6 Structure
  • Basic information

    1. Product Name: ACETYLNEURAMINYL HYDROLASE
    2. Synonyms: alpha-neuraminidase;EC 3.2.1.18;EC 3.2.1.18 TYPE II;EC 3.2.1.18 TYPE III;EC 3.2.1.18 TYPE V;EC 3.2.1.18 TYPE VI;EC 3.2.1.18 TYPE VI-A;EC 3.2.1.18 TYPE VIII
    3. CAS NO:9001-67-6
    4. Molecular Formula: NULL
    5. Molecular Weight: 0
    6. EINECS: 232-624-6
    7. Product Categories: N/A
    8. Mol File: 9001-67-6.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: white/lyophilized powder
    5. Density: 1.00 g/mL at 20 °C
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. Water Solubility: Soluble in water or 10mM phosphate buffer, pH 6.0
    10. CAS DataBase Reference: ACETYLNEURAMINYL HYDROLASE(CAS DataBase Reference)
    11. NIST Chemistry Reference: ACETYLNEURAMINYL HYDROLASE(9001-67-6)
    12. EPA Substance Registry System: ACETYLNEURAMINYL HYDROLASE(9001-67-6)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: 22-24/25
    4. RIDADR: UN3373 - class 6.2 Biological substance, Category B
    5. WGK Germany: 3
    6. RTECS: QQ3450000
    7. F: 3-10
    8. TSCA: Yes
    9. HazardClass: N/A
    10. PackingGroup: N/A
    11. Hazardous Substances Data: 9001-67-6(Hazardous Substances Data)

9001-67-6 Usage

Uses

Used in Research and Development:
ACETYLNEURAMINYL HYDROLASE is used as a research tool for studying the binding of human T lymphocytes in sheep pretreated with neuraminidase. It helps in understanding the interaction between the enzyme and immune cells, which can be useful in developing therapeutic strategies for various diseases.
Used in Cancer Research:
The enzyme is used in cancer research to investigate the effect of bile salts on the action of hydrolysis by neuraminidase. This can provide insights into the role of neuraminidase in tumor biology and its potential as a therapeutic target for cancer treatment.
Used in Glycoprotein Characterization:
ACETYLNEURAMINYL HYDROLASE is used as a deglycosylation enzyme to cleave sialic acid residues from glycoproteins, allowing for further characterization using techniques such as SDS-PAGE and MALDI-TOF MS. This helps in the purification, structural analysis, and sequencing of glycoproteins, as well as in removing heterogeneity and charge from them.
Used in Pharmaceutical Industry:
Neuraminidase from Vibrio cholera has been used in a study to describe a five-step purification method, which can be useful in the development of pharmaceutical products. The enzyme has also been used in a study to investigate the modification of leukemia L1210 tumor cells, indicating its potential use in the development of cancer therapies.

Biochem/physiol Actions

Vibrio cholerae neuraminidase has been shown to promote cholera toxin infection by binding the toxin and aiding in its uptake by cells.

Check Digit Verification of cas no

The CAS Registry Mumber 9001-67-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,0 and 1 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 9001-67:
(6*9)+(5*0)+(4*0)+(3*1)+(2*6)+(1*7)=76
76 % 10 = 6
So 9001-67-6 is a valid CAS Registry Number.

9001-67-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Neuraminidase from Vibrio cholerae

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:9001-67-6 SDS

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