9003-01-4 Usage
Uses
Used in Personal Care Industry:
Carbomer 940 is used as a thickening, dispersing, suspending, and emulsifying agent in pharmaceuticals, cosmetics, and paints. It helps in modifying aqueous formulations for end uses such as cleaners, binders, adhesives, and emulsion paints.
Used in Adhesive Industry:
Carbomer 940 is used as a thickening agent for adhesives, providing improved viscosity and performance.
Used in Ceramic Industry:
Carbomer 940 is used in ceramic applications to improve dry strength, dispersant action, and workability of the clays.
Used in Research and Development:
Carbomer 940 is used in the study of solute diffusion in Polyvinyl alcohol/PAA copolymer hydrogel and in synthesizing poly(N-isopropylacrylamide)-block-PAA copolymer, which responds to both temperature and pH stimuli.
Used in Drug Delivery Systems:
Carbomer 940 is used in preparing block copolymer of oligo(methyl methacrylate)/PAA for micellar delivery of hydrophobic drugs, enhancing the delivery and bioavailability of the drugs.
Used in Disposable Diapers:
Carbomer 940 is used in disposable diapers for its absorbent properties and ability to retain water.
Used in Ion Exchange Resins:
Carbomer 940 is used in ion exchange resins due to its high ion exchange capacity and ability to form membranes.
Production Methods
Carbomers are synthetic, high-molecular-weight, crosslinked polymers
of acrylic acid. These acrylic acid polymers are crosslinked
with allyl sucrose or allyl pentaerythritol. The polymerization
solvent used previously was benzene; however, some of the newer
commercially available grades of carbomer are manufactured using
either ethyl acetate or a cyclohexane–ethyl acetate cosolvent
mixture. The Carbopol ETD and Carbopol Ultrez polymers are
produced in the cosolvent mixture with a proprietary polymerization
aid.
Pharmaceutical Applications
Carbomers are used in liquid or semisolid pharmaceutical
formulations as rheology modifiers. Formulations include creams,
gels, lotions and ointments for use in ophthalmic, rectal,
topical and vaginal preparations. Carbomer grades with
residual benzene content greater than 2 ppm do not meet the
specifications of the PhEur 6.4 monograph. However, carbomer
having low residuals of other solvents than the ICH-defined ‘Class I
OVI solvents’ may be used in Europe. Carbomer having low
residuals of ethyl acetate, such as Carbopol 971P NF or Carbopol
974P NF, may be used in oral preparations, in suspensions, capsules
or tablets. In tablet formulations, carbomers are used as
controlled release agents and/or as binders. In contrast to linear
polymers, higher viscosity does not result in slower drug release
with carbomers. Lightly crosslinked carbomers (lower viscosity) are
generally more efficient in controlling drug release than highly
crosslinked carbomers (higher viscosity). In wet granulation
processes, water, solvents or their mixtures can be used as the
granulating fluid. The tackiness of the wet mass may be reduced by
including talc in the formulation or by adding certain cationic
species to the granulating fluid. However, the presence of
cationic salts may accelerate drug release rates and reduce
bioadhesive properties. Carbomer polymers have also been
investigated in the preparation of sustained-release matrix
beads, as enzyme inhibitors of intestinal proteases in
peptide-containing dosage forms, as a bioadhesive for a
cervical patch and for intranasally administered microspheres, in magnetic granules for site-specific drug delivery to
the esophagus, and in oral mucoadhesive controlled drug
delivery systems. Carbomers copolymers are also employed
as emulsifying agents in the preparation of oil-in-water emulsions
for external administration. Carbomer 951 has been investigated as
a viscosity-increasing aid in the preparation of multiple emulsion
microspheres. Carbomers are also used in cosmetics. Therapeutically,
carbomer formulations have proved efficacious in improving
symptoms of moderate-to-severe dry eye syndrome.
Safety
Carbomers are used extensively in nonparenteral products,
particularly topical liquid and semisolid preparations. Grades
polymerized in ethyl acetate may also be used in oral formulations. There is no evidence of systemic absorption of
carbomer polymers following oral administration. Acute oral
toxicity studies in animals indicate that carbomer 934P has a low
oral toxicity, with doses up to 8 g/kg being administered to dogs
without fatalities occurring. Carbomers are generally regarded as
essentially nontoxic and nonirritant materials; there is no
evidence in humans of hypersensitivity reactions to carbomers
used topically.
LD50 (guinea pig, oral): 2.5 g/kg for carbomer 934
LD50 (guinea pig, oral): 2.5 g/kg for carbomer 934P
LD50 (guinea pig, oral): 2.5 g/kg for carbomer 940
LD50 (mouse, IP): 0.04 g/kg for carbomer 934P
LD50 (mouse, IP): 0.04 g/kg for carbomer 940
LD50 (mouse, IV): 0.07 g/kg for carbomer 934P
LD50 (mouse, IV): 0.07 g/kg for carbomer 940
LD50 (mouse, oral): 4.6 g/kg for carbomer 934P
LD50 (mouse, oral): 4.6 g/kg for carbomer 934
LD50 (mouse, oral): 4.6 g/kg for carbomer 940
LD50 (rat, oral): 10.25 g/kg for carbomer 910
LD50 (rat, oral): 2.5 g/kg for carbomer 934P
LD50 (rat, oral): 4.1 g/kg for carbomer 934
LD50 (rat, oral): 2.5 g/kg for carbomer 940
LD50 (rat, oral): > 1g/kg for carbomer 941
No observed adverse effect level (NOAEL) (rat, dog, oral): 1.5 g/kg
for carbomer homopolymer type B.
storage
Carbomers are stable, hygroscopic materials that may be heated at
temperatures below 1048℃ for up to 2 hours without affecting their
thickening efficiency. However, exposure to excessive temperatures
can result in discoloration and reduced stability. Complete
decomposition occurs with heating for 30 minutes at 2608℃. Dry
powder forms of carbomer do not support the growth of molds and
fungi. In contrast, microorganisms grow well in unpreserved
aqueous dispersions, and therefore an antimicrobial preservative
such as 0.1% w/v chlorocresol, 0.18% w/v methylparaben–0.02%
w/v propylparaben, or 0.1% w/v thimerosal should be added. The
addition of certain antimicrobials, such as benzalkonium chloride
or sodium benzoate, in high concentrations (0.1% w/v) can cause
cloudiness and a reduction in viscosity of carbomer dispersions.
Aqueous gels may be sterilized by autoclaving with minimal
changes in viscosity or pH, provided care is taken to exclude oxygen
from the system, or by gamma irradiation, although this technique
may increase the viscosity of the formulation. At room
temperature, carbomer dispersions maintain their viscosity during
storage for prolonged periods. Similarly, dispersion viscosity is
maintained, or only slightly reduced, at elevated storage temperatures
if an antioxidant is included in the formulation or if the
dispersion is stored protected from light. Exposure to light causes
oxidation that is reflected in a decrease in dispersion viscosity.
Stability to light may be improved by the addition of 0.05–0.1%
w/v of a water-soluble UV absorber such as benzophenone-2 or
benzophenone-4 in combination with 0.05–0.1% w/v edetic acid.
Carbomer powder should be stored in an airtight, corrosionresistant
container and protected from moisture. The use of glass,
plastic, or resin-lined containers is recommended for the storage of
formulations containing carbomer.
Advantages
The advantages of acrylic resins are : Better stain protection (wash ability) Water resistance Better adhesion Better blocking ('strap down') Resist cracking and blistering better Resistance to alkali cleaners.
Current market and forecast
The global demand on acrylic resin approached roughly US $ 14.5 billion in 2011. With an annual growth rate of 4 - 5 % , the acrylic resin market is expected to reach US $ 16.6 billion by 2014 and US$22 billion by 2020. Acrylic resins are used in a wide range of applications for the outstanding chemical characteristics and unique aesthetic properties. Currently, the strongest demand comes from automotive and medical device markets, and paints & coatings, adhesive & sealant and construction & architecture are the major application markets for acrylic resin.
Formulae
Acrylic resin is a general term for any one of the plastics (resin) generated through chemical reaction by applying polymerization initiator and heat to a monomer. The chemical name for the resin produced from the methyl methacrylate monomer (MMA) is polymethyl methacrylate (PMMA). MMA is a transparent and colorless fluid substance.One of the main characteristic features of PMMA is its high transparency. With its high weather resistance, it has been known to last over 30 years, it does not easily turn yellow or crumble when exposed to sunlight. Polymethyl methacrylate is used not only for transparent windows in aquariums but also for various items such as signboards in places like convenience stores, taillights of automobiles, bathtub liners, sinks, cell phone display screens, backlight optical waveguides for liquid crystal displays (LCD) and so on.
Incompatibilities
Carbomers are discolored by resorcinol and are incompatible with
phenol, cationic polymers, strong acids, and high levels of
electrolytes. Certain antimicrobial adjuvants should also be avoided
or used at low levels. Trace levels of iron and other
transition metals can catalytically degrade carbomer dispersions.
Certain amino-functional actives form complexes with carbomer;
often this can be prevented by adjusting the pH of the
dispersion and/or the solubility parameter by using appropriate
alcohols and polyols.
Carbomers also form pH-dependent complexes with certain
polymeric excipients. Adjustment of pH and/or solubility parameter
can also work in this situation.
Regulatory Status
Included in the FDA Inactive Ingredients Database (oral suspensions,
tablets; ophthalmic, rectal, topical, transdermal preparations;
vaginal suppositories). Included in nonparenteral medicines licensed
in Europe. Included in the Canadian List of Acceptable Nonmedicinal
Ingredients.
Check Digit Verification of cas no
The CAS Registry Mumber 9003-01-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,0 and 3 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 9003-01:
(6*9)+(5*0)+(4*0)+(3*3)+(2*0)+(1*1)=64
64 % 10 = 4
So 9003-01-4 is a valid CAS Registry Number.
InChI:InChI=1/C3H4O2/c1-2-3(4)5/h2H,1H2,(H,4,5)
