9050-04-8 Usage
Uses
Used in Pharmaceutical Industry:
CARBOXYMETHYLCELLULOSE CALCIUM (1.5 G) (AS) is used as a tablet disintegrant for improving the disintegration and dissolution of tablets, which enhances the absorption and bioavailability of the active pharmaceutical ingredients.
Production Methods
Cellulose, obtained from wood pulp or cotton fibers, is carboxymethylated,
followed by conversion to the calcium salt. It is then
graded on the basis of its degree of carboxymethylation and
pulverized.
Pharmaceutical Applications
The main use of carboxymethylcellulose calcium is in tablet
formulations, where it is used as a binder, diluent,
and disintegrant. Although carboxymethylcellulose calcium is
insoluble in water, it is an effective tablet disintegrant as it swells to
several times its original bulk on contact with water. Concentrations
up to 15% w/w may be used in tablet formulations; above this
concentration, tablet hardness is reduced.
Carboxymethylcellulose calcium is also used in other applications
similarly to carboxymethylcellulose sodium; for example, as a
suspending or viscosity-increasing agent in oral and topical
pharmaceutical formulations. Carboxymethylcellulose calcium is
also used in modern wound dressings for its water absorption,
retention and hemostatic properties.
Safety
Carboxymethylcellulose calcium is used in oral and topical
pharmaceutical formulations, similarly to carboxymethylcellulose
sodium, and is generally regarded as a nontoxic and nonirritant
material. However, as with other cellulose derivatives, oral
consumption of large amounts of carboxymethylcellulose calcium
may have a laxative effect.
storage
Carboxymethylcellulose calcium is a stable, though hygroscopic
material. It should be stored in a well-closed container in a cool, dry
place.
Regulatory Status
Included in the FDA Inactive Ingredients Database (oral, capsules
and tablets). Included in nonparenteral medicines licensed in the
UK. Included in the Canadian List of Acceptable Non-medicinal
Ingredients.
Check Digit Verification of cas no
The CAS Registry Mumber 9050-04-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,5 and 0 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 9050-04:
(6*9)+(5*0)+(4*5)+(3*0)+(2*0)+(1*4)=78
78 % 10 = 8
So 9050-04-8 is a valid CAS Registry Number.
