905587-08-8

Basic information

• Product Name: 2,3,6-Trifluoro-5-nitropyridine
• Synonyms: 2,3,6-Trifluoro-5-nitropyridine
• CAS NO: 905587-08-8
• Molecular Formula: C₅HF₃N₂O₂
• Molecular Weight: 178.0688496
• Mol File: 905587-08-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,3,6-Trifluoro-5-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,6-Trifluoro-5-nitropyridine(905587-08-8)
• EPA Substance Registry System: 2,3,6-Trifluoro-5-nitropyridine(905587-08-8)

Safety Data

• Hazardous Substances Data: 905587-08-8(Hazardous Substances Data)

Usage

General Description

2,3,6-Trifluoro-5-nitropyridine is a chemical compound with the molecular formula C5H2F3N2O2. It is a yellow crystalline solid with a molecular weight of 174.08 g/mol. 2,3,6-Trifluoro-5-nitropyridine is often used in the pharmaceutical industry as an intermediate for the synthesis of various drugs and agrochemicals. It is also utilized in the development of organic compounds and materials. 2,3,6-Trifluoro-5-nitropyridine is known for its strong electron-withdrawing properties, making it a valuable building block for the creation of complex organic molecules. Overall, this chemical plays a crucial role in the production of pharmaceuticals and other important compounds.

Upstream product

• 3512-18-3 2,3,6-trifluoropyridine 

Downstream Products

• 1404085-83-1 N-(3,5-difluorophenyl)-5-fluoro-6-methoxy-3-nitropyridin-2-amine 
• 1404085-71-7 5-fluoro-6-methoxy-3-nitro-N-phenylpyridin-2-amine 
• 907218-76-2 (R)-2-(5,6-difluoro-3-nitropyridin-2-ylamino)-2-(4-fluorophenyl)ethanol 

Relevant articles and documents

Discovery of disubstituted imidazo[4,5- b ]pyridines and purines as potent TrkA inhibitors

Trk receptor tyrosine kinases have been implicated in cancer and pain. A crystal structure of TrkA with AZ-23 (1a) was obtained, and scaffold hopping resulted in two 5/6-bicyclic series comprising either imidazo[4,5-b]pyridines or purines. Further optimization of these two fusion series led to compounds with subnanomolar potencies against TrkA kinase in cellular assays. Antitumor effects in a TrkA-driven mouse allograft model were demonstrated with compounds 2d and 3a.

IMIDAZOPYRIDINE DERIVATIVES AS PI3K INHIBITORS

New imidazopyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositide 3-Kinases (PI3Ks).

9- (PYRAZOL- 3 -YL) - 9H- PURINE-2 -AMINE AND 3- (PYRAZ0L-3-YL) -3H-IMIDAZ0 [4, 5-B] PYRIDIN-5-AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER

The present invention relates to compounds of Formula (I): and to their pharmaceutical compositions, and to their methods of use. These compounds provide a treatment for myeloproliferative disorders and cancer.