90819-30-0

Basic information

• Product Name: (S)-2-TERT-BUTOXYCARBONYLAMINO-3-(3-HYDROXY-PHENYL)-PROPIONIC ACID
• Synonyms: 2(S)-TERT-BUTOXYCARBONYLAMINO-3-(3-HYDROXY-PHENYL)-PROPIONIC ACID;BOC-3-HYDROXY-L-PHENYLALANINE;BOC-M-TYR-OH;BOC-L-META-TYROSINE;BOC-L-PHE(3-OH)-OH;BOC-L-M-TYR;(S)-2-TERT-BUTOXYCARBONYLAMINO-3-(3-HYDROXY-PHENYL)-PROPIONIC ACID;N-Boc-3-hydroxy-L-phenylalanine
• CAS NO: 90819-30-0
• Molecular Formula: C₁₄H₁₉NO₅
• Molecular Weight: 281.3
• Mol File: 90819-30-0.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Store at 0-5°C
• CAS DataBase Reference: (S)-2-TERT-BUTOXYCARBONYLAMINO-3-(3-HYDROXY-PHENYL)-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-TERT-BUTOXYCARBONYLAMINO-3-(3-HYDROXY-PHENYL)-PROPIONIC ACID(90819-30-0)
• EPA Substance Registry System: (S)-2-TERT-BUTOXYCARBONYLAMINO-3-(3-HYDROXY-PHENYL)-PROPIONIC ACID(90819-30-0)

Safety Data

• Hazardous Substances Data: 90819-30-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(S)-2-TERT-BUTOXYCARBONYLAMINO-3-(3-HYDROXY-PHENYL)-PROPIONIC ACID is used as a building block in peptide synthesis for the development of new pharmaceuticals, leveraging its ability to modify and protect the structure of amino acids during the synthesis process.
Used in Drug Development:
In the field of drug development, (S)-2-TERT-BUTOXYCARBONYLAMINO-3-(3-HYDROXY-PHENYL)-PROPIONIC ACID is utilized as a key component in the design and synthesis of innovative drugs, particularly those targeting inflammation and related conditions.
Used in Anti-Inflammatory Drug Development:
(S)-2-TERT-BUTOXYCARBONYLAMINO-3-(3-HYDROXY-PHENYL)-PROPIONIC ACID is employed as a potential active pharmaceutical ingredient in the development of anti-inflammatory drugs, capitalizing on its inherent anti-inflammatory properties to treat various inflammatory disorders.

Upstream product

• 775-06-4 D/L-3-hydroxy-phenylalanine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 587-33-7 m-tyrosine 
• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 

Downstream Products

• 162538-23-0 [(S)-1-(3-Benzyloxy-benzyl)-3-((S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester 
• 162538-24-1 [(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-1-(3-hydroxy-benzyl)-propyl]-carbamic acid tert-butyl ester 
• 1026869-14-6 [(S)-1-(3-Benzyloxy-benzyl)-3-chloro-2-oxo-propyl]-carbamic acid tert-butyl ester 
• 162536-46-1 (S)-3-(3-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid 
• 162536-45-0 benzyl (S)-3-(3-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)propanoate 
• 90819-37-7 Boc-L-m-Tyr-Gly-Gly-L-Phe-L-Leu-OEt 
• 1175919-93-3 C₁₇H₂₃NO₅ 

Relevant articles and documents

Elucidating the Structural Requirement of Uridylpeptide Antibiotics for Antibacterial Activity

The synthesis and biological evaluation of analogues of uridylpeptide antibiotics were described, and the molecular interaction between the 3′-hydroxy analogue of mureidomycin A (3′-hydroxymureidomycin A) and its target enzyme, phospho-MurNAc-pentapeptide

Aminodiol HIV protease inhibitors. Synthesis and structure - Activity relationships of P1/P1′ compounds: Correlation between lipophilicity and cytotoxicity

A series of novel aminodiol inhibitors of HIV protease based on the lead compound 1 with structural modifications at P1′ were synthesized in order to reduce the cytotoxicity of 1. We have observed a high degree of correlation between the lipophilicity and the cytotoxicity of this series of inhibitors. It was found that appropriate substitution at the para position of the P1′ phenyl group of 1 resulted in the identification of equipotent (both against the enzyme and in cell culture) compounds (101, 10m, 10n, and 15c) which possess significantly decreased cytotoxicity.