908283-37-4Relevant articles and documents
Synthesis and structure based optimization of novel Akt inhibitors
Lippa, Blaise,Pan, Gonghua,Corbett, Matthew,Li, Chao,Kauffman, Goss S.,Pandit, Jayvardhan,Robinson, Shaughnessy,Wei, Liuqing,Kozina, Ekaterina,Marr, Eric S.,Borzillo, Gary,Knauth, Elisabeth,Barbacci-Tobin, Elsa G.,Vincent, Patrick,Troutman, Merin,Baker, Deborah,Rajamohan, Francis,Kakar, Shefali,Clark, Tracey,Morris, Joel
body text, p. 3359 - 3363 (2009/04/05)
Based on a high throughput screening hit, pyrrolopyrimidine inhibitors of the Akt kinase are explored. X-ray co-crystal structures of two lead series results in the understanding of key binding interactions, the design of new lead series, and enhanced pot