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91089-54-2

91089-54-2

91089-54-2

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Synonyms:

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Chemical Properties

Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 3 Articles be found

Inhibitors Targeting STAT5 Signaling in Myeloid Leukemias: New Tetrahydroquinoline Derivatives with Improved Antileukemic Potential

Polomski, Marion,Brachet-Botineau, Marie,Juen, Ludovic,Viaud-Massuard, Marie-Claude,Gouilleux, Fabrice,Prié, Gildas

supporting information, p. 1034 - 1046 (2021/01/25)

Signal transducers and activators of transcription 5A and 5B (STAT5A and STAT5B) are two closely related STAT family members that are crucial downstream effectors of tyrosine kinase oncoproteins such as FLT3-ITD in acute myeloid leukemia (AML) and BCR-ABL

Photoinduced Cyclizations of Mono- and Dianions of N-Acyl-o-chloroanilines and N-Acyl-o-chlorobenzylamines as General Methods for the Synthesis of Oxindoles and 1,4-Dihydro-3(2H)-isoquinolinones

Goehring, R. Richard,Sachdeva, Yesh P.,Pisipati, Jyothi S.,Sleevi, Mark C.,Wolfe, James F.

, p. 435 - 443 (2007/10/02)

Formation of the monoanions of a series of N-acyl-N-alkyl-o-chloroanilines by means of LDA in THF followed by irradiation with near-UV light affords 1,3-dialkyloxindoles in good yields.Similar photoinduced cyclizations of dianions derived from N-acyl-o-chloroanilines leads to 3-alkyloxindoles.Photocyclizations of mono- and dianion prepared from α,β-unsaturated o-haloanilides proceed to form 3-alkylideneoxindoles.Carbanions derived from N-acyl-o-chlorobenzylamines also undergo photoassisted ring closure to afford 1,4-dihydro-3(2H)-isoquinolinones.The influence of near-UV light and the effect of inhibitors implicate a radical-chain mechanism as the major reaction pathway in this convenient new method for oxindole and isoquinolinone synthesis.

Process route upstream and downstream products

Process route

3,3-Dimethylacryloyl chloride
3350-78-5

3,3-Dimethylacryloyl chloride

o-chloroaniline
95-51-2

o-chloroaniline

N-(2-chlorophenyl)-3-methylbut-2-enamide
91089-54-2

N-(2-chlorophenyl)-3-methylbut-2-enamide

Conditions
Conditions Yield
With pyridine; at 0 - 20 ℃; for 5h; Inert atmosphere;
92%
With sodium carbonate; In benzene; for 2h;
N-(2-chlorophenyl)-3-methylbut-2-enamide
91089-54-2

N-(2-chlorophenyl)-3-methylbut-2-enamide

Conditions
Conditions Yield
N-(2-chlorophenyl)-3-methylbut-2-enamide
91089-54-2

N-(2-chlorophenyl)-3-methylbut-2-enamide

3-Methyl-but-3-enoic acid (2-chloro-phenyl)-amide
93646-43-6

3-Methyl-but-3-enoic acid (2-chloro-phenyl)-amide

Conditions
Conditions Yield
With lithium diisopropyl amide; In tetrahydrofuran; for 3h;
72%
N-(2-chlorophenyl)-3-methylbut-2-enamide
91089-54-2

N-(2-chlorophenyl)-3-methylbut-2-enamide

3-Methyl-but-3-enoic acid (2-chloro-phenyl)-methyl-amide
93646-37-8

3-Methyl-but-3-enoic acid (2-chloro-phenyl)-methyl-amide

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: KOH / acetone
2: 90 percent / KNH2, p-dinitrobenzene / liquid ammonia; diethyl ether / 0.25 h
With para-dinitrobenzene; potassium hydroxide; potassium amide; In diethyl ether; ammonia; acetone;
N-(2-chlorophenyl)-3-methylbut-2-enamide
91089-54-2

N-(2-chlorophenyl)-3-methylbut-2-enamide

methyl iodide
74-88-4

methyl iodide

3-methyl-crotonic acid-(2-chloro-<i>N</i>-methyl-anilide)
93646-33-4

3-methyl-crotonic acid-(2-chloro-N-methyl-anilide)

Conditions
Conditions Yield
With potassium hydroxide; In acetone;
N-(2-chlorophenyl)-3-methylbut-2-enamide
91089-54-2

N-(2-chlorophenyl)-3-methylbut-2-enamide

8-chloro-4,4-dimethyl-3,4-dihydroquinolin-2(1H)-one
676116-21-5

8-chloro-4,4-dimethyl-3,4-dihydroquinolin-2(1H)-one

Conditions
Conditions Yield
With aluminum (III) chloride; In dichloromethane; at 0 - 20 ℃; for 1.5h; Inert atmosphere;
77%
N-(2-chlorophenyl)-3-methylbut-2-enamide
91089-54-2

N-(2-chlorophenyl)-3-methylbut-2-enamide

1-methyl-3-(propan-2-ylidene)indoline-2-one
4679-81-6

1-methyl-3-(propan-2-ylidene)indoline-2-one

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: KOH / acetone
2: 100 percent Chromat. / KNH2 / liquid ammonia; diethyl ether / 0.25 h / Irradiation
With potassium hydroxide; potassium amide; In diethyl ether; ammonia; acetone;
N-(2-chlorophenyl)-3-methylbut-2-enamide
91089-54-2

N-(2-chlorophenyl)-3-methylbut-2-enamide

3-Isopropylidene-1,3-dihydro-indol-2-one
5085-04-1

3-Isopropylidene-1,3-dihydro-indol-2-one

Conditions
Conditions Yield
With lithium diisopropyl amide; In tetrahydrofuran; for 3h; Irradiation;
89%

91089-54-2 Upstream products

91089-54-2 Downstream products

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