91344-86-4Relevant articles and documents
Synthesis method of 3, 5-disubstituted 1, 2, 4-oxadiazole
-
Paragraph 0027-0030, (2021/06/22)
The invention relates to a novel synthetic method for synthesizing 3, 5-disubstituted-1, 2, 4-oxadiazole, in particular to a synthetic method of 3, 5-disubstituted-1, 2, 4-oxadiazole. The method disclosed by the invention has the characteristics that the reaction is carried out at room temperature, the 1, 2, 4-oxadiazole is synthesized at high yield by a one-pot method, and a final product does not need to be subjected to column chromatography. The 3, 5-disubstituted-1, 2, 4-oxadiazole synthesized by the invention can be used in the field of medical treatment.
Direct Amidation of Carboxylic Acids through an Active α-Acyl Enol Ester Intermediate
Xu, Xianjun,Feng, Huangdi,Huang, Liliang,Liu, Xiaohui
, p. 7962 - 7969 (2018/06/18)
The development of a highly efficient and simple protocol for the direct amidation of carboxylic acids is described employing ynoates as novel coupling reagents. The transformation proceeds in good to excellent yields via in situ α-acyl enol ester intermediates formation under mild reaction conditions. This useful method has been demonstrated for a range of substrates to provide a succinct access to structurally diverse amides, including key intermediates of glibenclamide, tiapride hydrochloride, and nateglinide, and can be conducted on a mole scale.