914076-14-5Relevant articles and documents
Catalytic site-selective synthesis and evaluation of a series of erythromycin analogs
Lewis, Chad A.,Merkel, Janie,Miller, Scott J.
supporting information; experimental part, p. 6007 - 6011 (2009/06/25)
The generation of a series of analogs of erythromycin A (EryA, 2) is described. In this study, we compared two peptide-based catalysts-one originally identified from a catalyst screen (5) and its enantiomer (ent-5)-for the selective functionalization of EryA. The semi-synthetic analogs were subjected to MIC evaluation with two bacterial strains and compared to unfunctionalized EryA.
