914912-73-5

Basic information

• Product Name: 1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-2-C-methyl-D-ribofuranose
• Synonyms: 1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-2-C-methyl-D-ribofuranose
• CAS NO: 914912-73-5
• Molecular Weight: 478.474
• Mol File: 914912-73-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-2-C-methyl-D-ribofuranose(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-2-C-methyl-D-ribofuranose(914912-73-5)
• EPA Substance Registry System: 1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-2-C-methyl-D-ribofuranose(914912-73-5)

Safety Data

• Hazardous Substances Data: 914912-73-5(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 879551-04-9 (3R,4R,5R)-3?fluoro?4?hydroxy?5?(hydroxymethyl)?3?methyltetrahydrofuran?2?one 
• 55775-39-8 1-O-methyl-3,5-di-O-benzyl-D-ribofuranoside 
• 817204-31-2 methyl 3,5-di-O-benzoyl-2-deoxy-2-fluoro-2-C-methyl-β-D-ribofuranoside 
• 817204-29-8 methyl 3,5-di-O-benzyl-2-C-methyl-β-D-arabinofuranoside 
• 817204-30-1 methyl 3,5-di-O-benzyl-2-deoxy-2-fluoro-2-C-methyl-β-D-ribofuranoside 

Downstream Products

• 817204-32-3 (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate 
• 863329-65-1 (2‘R)-2‘-deoxy-2’-fluoro-2-methyluridine-3’,5’-dibenzoate 

Relevant articles and documents

Preparation method of (2'R)-2'-deoxy-2'-fluoro-2'-methyluridine

The invention relates to the technical field of medicinal chemistry, in particular to a preparation method of (2'R)-2'-deoxy-2'-fluoro-2'-methyluridine. According to the method, (2R)-2-deoxy-2-fluoro-2-methyl-D-erythropentonic acid GAMMA-lactone is taken as a raw material and is subjected to reduction and protection, a fluoro ribose fragment with three identical protection groups is obtained and directly reacts with uracil, deprotection is performed, and a target compound is obtained. Compared with an existing technical route adopting an eight-step reaction, the route of the preparation method is shortened to adopt four steps, and the problems that the existing technical route adopts complicated steps, the atom economy is low, the cost is high and the like are effectively solved; besides, an obtained intermediate can be recrystallized and refined, the whole route is simple, and the method is convenient to operate, high in yield and suitable for large-scale industrial production.