915086-94-1

Basic information

• Product Name: 4-{4-[7-(4-cyano-3-trifluoromethylphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]phenyl}butanoic acid
• Synonyms: 4-{4-[7-(4-cyano-3-trifluoromethylphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]phenyl}butanoic acid
• CAS NO: 915086-94-1
• Molecular Weight: 487.502
• Mol File: 915086-94-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-{4-[7-(4-cyano-3-trifluoromethylphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]phenyl}butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{4-[7-(4-cyano-3-trifluoromethylphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]phenyl}butanoic acid(915086-94-1)
• EPA Substance Registry System: 4-{4-[7-(4-cyano-3-trifluoromethylphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]phenyl}butanoic acid(915086-94-1)

Safety Data

• Hazardous Substances Data: 915086-94-1(Hazardous Substances Data)

Upstream product

• 915086-92-9 4-[4-(1-cyanocyclobutylamino)phenyl]butanoic acid 
• 143782-23-4 4-isothiocyanato 2-(trifluoromethyl)benzonitrile 

Relevant articles and documents

Structure-activity relationship for thiohydantoin androgen receptor antagonists for castration-resistant prostate cancer (CRPC)

A structure-activity relationship study was carried out on a series of thiohydantoins and their analogues 14 which led to the discovery of 92 (MDV3100) as the clinical candidate for the treatment of hormone refractory prostate cancer.

Diarylthiohydantoin compounds

The present invention relates to diarylthiohydantoin compounds and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.