91748-02-6Relevant articles and documents
Protein–ligand interaction-guided discovery of novel VEGFR-2 inhibitors
Zhang, Yanmin,Zhang, Mingliang,Wang, Yuchen,Fan, Yuanrong,Chen, Xingye,Yang, Yan,Hua, Yi,Xie, Wuchen,Lu, Tao,Tang, Weifang,Chen, Yadong,Liu, Haichun
, p. 2559 - 2574 (2020)
As an effective target in abnormal angiogenesis-related tumor treatment, VEGFR-2 has small-molecule inhibitors of various scaffolds being approved for treating diseases such as renal carcinoma, non-small cell lung cancer, etc. However, endogenous and acqu
Electrogenerated Base (EG Base) Induced Hydroxymethylation of the Side Chain of Nitroalkylbenzenes with Paraformaldehyde
Torii, Sigeru,Murakami, Yasuo,Tanaka, Hideo,Okamoto, Koichi
, p. 3143 - 3147 (2007/10/02)
Hydroxymethylation of nitroalkylbenzenes with paraformaldehyde was accomplished by electrolysis in a (CH2O)n-DMF-Et4NOTs-(Pt electrode) system.The reaction was found to be catalytic (0.25 faraday/mol) and dependent on the electroreduction of formaldehyde and/or nitroalkylbenzene.A variety of nitroalkylbenzenes were transformed to their corresponding mono- and/or bishydroxymethylated derivatives in good yield.The product yield and selectivity were shown to depend on the order of reagent addition, solvent, supporting electrolyte, and structure of the starting nitroalkylbenzenes.A plausible mechanism of the generation of base catalysts (EG base) in electroreductive media is discussed.