91898-11-2Relevant articles and documents
Melamine trisulfonic acid (MTSA): A new efficient catalyst for the chemoselective methoxymethylation of alcohols
Shirini, Farhad,Zolfigol, Mohammad Ali,Albadi, Jalal
, p. 910 - 914 (2010)
Melamine trisulfonic acid, which is easily prepared by the reaction of melamine with neat chlorosulfonic acid, is able to efficiently catalyze the chemoselective methoxymethylation of alcohols with dimethoxymethane (DMM). All reactions were performed unde
A chloromethyl methyl ether and its armor oxygen methyl protection method for the synthesis of the compounds of
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Paragraph 0053; 0054; 0055; 0056, (2016/10/10)
The invention provides chloromethyl methyl ether and a synthesis method of a compound protected by methoxymethyl thereof. The chloromethyl methyl ether (MOMCl) is a common protective reagent in organic synthesis. Commonly used synthesis methods are tedious in operation and long in reaction time. The synthesis method provided by the invention comprises: with trifluoromethane sulfonic acid or perchloric acid as a catalyst, reacting acyl chloride with dimethoxymethane to synthesize the chloromethyl methyl ether. The chloromethyl methyl ether produced in situ can directly act with a hydroxyl compound and organic alkali dissolved in an organic solvent to generate a product with hydroxyl protected by MOM. The method has the advantages of high reaction speed and simple reaction operation. Therefore, the method can be applicable to the production and application of a continuous flow reactor.
A mild and efficient method for the methoxymethylation and acetylation of alcohols promoted by benzyltriphenylphosphonium tribromide
Shirini, Farhad,Imanzadeh, Gholam Hossein,Mousazadeh, Seyyed Ali Reza,Mohammadpoor-Baltork, Iraj,Abedin, Masoumeh
experimental part, p. 1187 - 1190 (2011/10/05)
A mild and efficient method for the conversion of alcohols to their corresponding methoxymethyl ethers and acetates using benzyltriphenylphosphonium tribromide (BTPTB) as catalyst is described. All reactions were performed under completely heterogeneous reaction conditions in good to high yields.