92-61-5Relevant articles and documents
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Braymer et al.
, p. 163 (1960)
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Coumarins from Astragalus asper
Guzhva
, p. 767 - 768 (2008)
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COUMARIN COMPOSITION OF Haplophyllum bungei
Abyshev, A. Z.,Gashimov, N. F.
, p. 615 - 616 (1982)
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A COUMARIN GLUCOSIDE FROM XEROMPHIS OBOVATA
Sibanda, S.,Ndengu, B.,Multari, G.,Pompi, V.,Galeffi, C.
, p. 1550 - 1552 (1989)
From root bark of Xeromphis obovata three coumarins have been isolated: scopoletin, its 7-β-D-glucopyranoside (scopolin) and the new β-D-apiosyl-(1" -> 6)-β-D-glucopyranoside of scopoletin, named xeroboside.Also two iridoids, deacetylasperulosidic acid methyl ester and gardenoside, have been isolated and identified as the corresponding acetyl derivetives. Key Word Index-Xeromphis obovata; Rubiaceae; coumarins; iridoids; xeroboside.
COUMARINS OF Ptarmica bisserata
Davidyats, E. S.
, p. 233 (1982)
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Novel NO-releasing scopoletin derivatives induce cell death via mitochondrial apoptosis pathway and cell cycle arrest
Chen, Cheng,Chen, Li,Lei, Zhichao,Li, Na,Shi, Zhixian,Sun, Jianbo,Wang, Yujin
, (2020/05/19)
A series of phenylsulfonyfuroxan-based NO-releasing scopoletin derivatives were designed and synthesized in the study. All target compounds showed significantly improved antiproliferative activity against four cancer cell lines (MDA-MB-231, MCF-7, HepG2 and A459) and lower cytotoxicity toward normal liver LO2 cells. Derivative 47 concentration-dependently inhibited the colony formation of MDA-MB-231 cells. NO-releasing assessment indicated that the intracellular NO level was almost positively correlated with the antiproliferative ability. Compound 47, which released the highest amounts of NO, showed the best potency (IC50 = 1.23 μM) against MDA-MB-231 cells. Mechanism research revealed for the first time that 47 blocked the proliferation of MDA-MB-231 cells by activating mitochondrial apoptosis pathway and arresting cell cycle at G2/M phase. Taken together, as a novel scopoletin derivative, 47 exhibited excellent inhibitory effects against malignant cancer cells and lower toxicity on normal cells. Thus, an in-depth evaluation of 47 to explore its complete therapeutic potential for cancer treatment is warranted.
Escoparone chemical whole synthetic method
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, (2019/05/15)
The invention discloses escoparone chemical whole synthetic method, which belongs to the technical field of chemical synthesis, escoparone chemical full-synthetic method is 2, 4, 5 - trimethoxybenzaldehyde de-methyl generating 4 - dihydroxy - 5 - methoxybenzaldehyde; 4 - dihydroxy - 5 - methoxy benzaldehyde with malonic acid to generate the cyclization reaction to produce the 3 - carboxyl scopolamine lactone; 3 - carboxyl scopolamine lactone by microwave auxiliary decarboxylative generating scopolamine lactone; scopolamine lactone by methylation get escoparone, aims to solve the low efficiency of the plant extract, the disadvantage of low yield and the synthetic yield is low, high cost, is not suitable for the industrial application of the shortcomings.