923022-44-0

Basic information

• Product Name: 1(2H)-Isoquinolinone, 7-bromo-6-fluoro-2-[(4-methoxyphenyl)methyl]-
• CAS NO: 923022-44-0
• Molecular Formula: C17H13BrFNO2
• Molecular Weight: 362.198
• Mol File: 923022-44-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1(2H)-Isoquinolinone, 7-bromo-6-fluoro-2-[(4-methoxyphenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1(2H)-Isoquinolinone, 7-bromo-6-fluoro-2-[(4-methoxyphenyl)methyl]-(923022-44-0)
• EPA Substance Registry System: 1(2H)-Isoquinolinone, 7-bromo-6-fluoro-2-[(4-methoxyphenyl)methyl]-(923022-44-0)

Safety Data

• Hazardous Substances Data: 923022-44-0(Hazardous Substances Data)

Usage

Chemical Class

Isoquinolinones

Explanation

The compound belongs to the class of isoquinolinones, which are a group of organic compounds with a fused isoquinoline ring system.

Explanation

The compound has a bromine atom attached at the 7th position of the isoquinolinone ring, which can influence its chemical reactivity and properties.

Explanation

A fluorine atom is present at the 6th position of the isoquinolinone ring, which can affect the compound's lipophilicity, metabolic stability, and binding affinity.

Explanation

The compound features a 4-methoxyphenylmethyl group attached to the 2nd position of the isoquinolinone ring, which can impact its steric properties and potential interactions with biological targets.
5. Potential Pharmaceutical Properties

Explanation

The compound is being studied for its potential use in the development of drugs for various medical conditions due to its unique structural features and properties.
6. Medicinal Chemistry Research

Bromine Substitution

7-bromo

Fluorine Substitution

6-fluoro

4-Methoxyphenylmethyl Substitution

2-[(4-methoxyphenyl)methyl]

Upstream product

• 923022-43-9 7-bromo-6-fluoro-2H-isoquinolin-1-one 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 923266-07-3 4-[7-bromo-2-(4-methoxy-benzyl)-1-oxo-1,2-dihydro-isoquinolin-6-yloxy]-piperidine-1-carboxylic acid tert-butyl ester 
• 923022-82-6 7-benzylsulfanyl-6-fluoro-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one 

Relevant articles and documents

CYCLOHEXYLAMIN ISOQUINOLONE DERIVATIVES AS RHO-KINASE INHIBITORS

The invention relates to 6-cyclohexylamine-substituted isoquinolone derivatives of the formula (I) or isoquinoline derivatives of the formula (I’) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.