923289-59-2

Basic information

• Product Name: 4-Isopropylthiazole-2-carbonyl chloride
• Synonyms: 4-Isopropylthiazole-2-carbonyl chloride;4-(propan-2-yl)-1,3-thiazole-2-carbonyl chloride;MILXVFASHGWQQV-UHFFFAOYSA-N
• CAS NO: 923289-59-2
• Molecular Formula: C₇H₈ClNOS
• Molecular Weight: 189.66252
• Mol File: 923289-59-2.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Isopropylthiazole-2-carbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Isopropylthiazole-2-carbonyl chloride(923289-59-2)
• EPA Substance Registry System: 4-Isopropylthiazole-2-carbonyl chloride(923289-59-2)

Safety Data

• Hazardous Substances Data: 923289-59-2(Hazardous Substances Data)

Usage

General Description

4-Isopropylthiazole-2-carbonyl chloride is a chemical compound that belongs to the thiazole class. It is used in organic synthesis as a versatile building block for the preparation of various pharmaceuticals and agrochemicals. 4-Isopropylthiazole-2-carbonyl chloride is known for its strong potential as an intermediate in the production of thiazole-based compounds, which have applications in the pharmaceutical industry. Additionally, it serves as a key starting material for the synthesis of biologically active molecules and can be utilized in the development of new drugs and medicinal compounds. Its unique structure and properties make it a valuable tool for synthetic chemists and researchers in the development of novel organic molecules.

Upstream product

• 563-80-4 3-methyl-butan-2-one 
• 156589-82-1 4-(1-methylethyl)thiazole-2-carboxylic acid ethyl ester 
• 79-37-8 oxalyl dichloride 
• 1108658-73-6 4-isopropylthiazole-2-carboxylic acid 
• 300831-06-5 4-isopropylthiazole-2-carboxylic acid 
• 19967-55-6 1-bromo-3-methyl-2-butanone 

Downstream Products

• 42465-53-2 1-(2-amino-4-methoxyphenyl)ethanone 
• 300831-07-6 N-(2-acetyl-5-methoxyphenyl)-4-isopropylthiazole-2-carboxamide 
• 1108658-94-1 N-(6-acetyl-3-chloro-4-methoxyphenyl)-4-isopropylthiazole-2-carboxamide 
• 923289-21-8 8-methyl-2-[4-(1-methylethyl)-1,3-thiazol-2-yl]-7-(methyloxy)-4-quinolinol 
• 923289-20-7 N-(6-acetyl-2-methyl-3-methoxyphenyl)-4-isopropylthiazole-2-carboxamide 

Relevant articles and documents

2-(1H-INDOLE-3-CARBONYL)-THIAZOLE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS

2-(1H-lndole-3-carbonyl)-thiazole-4-carboxamide derivatives and the corresponding imidazole, oxazole and thiophene derivatives and related compounds as aryl hydrocarbon receptor (AHR) agonists for the treatment of angiogenesis implicated disorders, such as e.g. retinopathy, psoriasis, rheumatoid arthritis, obesity and cancer, or inflammatory disorders. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 27 to 32 and 59 to 219; examples 1 to 8; compounds 1-1 to 1-97; tables 1-a, 2 and 3).

COMPOUNDS AS HEPATITIS C INHIBITORS AND USES THEREOF IN MEDICINE

Provided herein are compounds as hepatitis C inhibitors and uses thereof in medicine. Specifically, provided herein is a compound of Formula (I) or a stereoisomer, a tautomer, an enantiomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, which can be used for treating HCV infection or hepatitis C diseases. Also provided herein are a pharmaceutically acceptable composition containing such compound and a method of treating HCV infection or hepatitis C diseases comprising administering the compound or pharmaceutical composition thereof disclosed herein.

MACROCYCLIC SERINE PROTEASE INHIBITORS USEFUL AGAINST VIRAL INFECTIONS, PARTICULARLY HCV

Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula (Ia) or (Ib), pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.