92557-51-2Relevant articles and documents
Oxidized graphitic carbon nitride as a sustainable metal-free catalyst for hydrogen transfer reactions under mild conditions
Bahuguna, Ashish,Choudhary, Priyanka,Dhankhar, Sandeep Singh,Krishnan, Venkata,Kumar, Ajay,Nagaraja, C. M.
, p. 5084 - 5095 (2020/08/25)
The development of green and sustainable transfer hydrogenation protocols without the use of expensive noble metals and toxic solvents is a challenging task. Herein, a highly stable, low-cost, metal-free heterogeneous catalyst, oxidized graphitic carbon nitride (O-GCN), has been developed, which exhibits efficient catalytic hydrogen transfer reactions of carbonyl compounds to corresponding alcohols under mild reaction conditions. The heterogeneous catalyst was synthesized by the chemical oxidation of graphitic carbon nitride (GCN) nanosheets, which results in the generation of carboxyl, hydroxyl and ketone groups over the GCN surface. These hydrophilic groups functionalized on the surface of O-GCN nanosheets act as catalytically active sites for the hydrogen transfer reactions of carbonyl compounds. A wide range of substrates was investigated for the hydrogen transfer reactions using 2-propanol both as a hydrogen donor and a solvent. The O-GCN nanosheets resulted in high yields and high turnover numbers (TON) demonstrating the versatile catalytic potential of the as-synthesized catalyst. The detailed optimization of the reaction parameters (temperature, time and catalyst amount) was performed, in addition to the calculation of green metric parameters. Moreover, the catalyst could be easily recovered and was used for five runs without any significant loss in catalytic activity. This study provides a green, sustainable, attractive, and useful methodology for the hydrogen transfer reactions of a wide range of carbonyl compounds.
Regioselective hydroarylation reactions of C3 electrophilic N-acetylindoles activated by FeCl3: An entry to 3-(Hetero)arylindolines
Beaud, Rodolphe,Guillot, Regis,Kouklovsky, Cyrille,Vincent, Guillaume
supporting information, p. 7492 - 7500 (2014/06/23)
A method for the direct and rare umpolung of the 3 position of indoles is reported. The activation of N-acetylindole with iron(III) chloride allows the C-H addition of aromatic and heteroaromatic substrates to the C2-C3 double bond of the indole nucleus to generate a quaternary center at C3 and leads regioselectively to 3-arylindolines. Optimization, scope (50 examples), practicability (gram scale, air atmosphere, room temperature), and mechanistic insights of this process are presented. Synthetic transformations of the indoline products into drug-like compounds are also described.
Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
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Page/Page column 19, (2008/06/13)
Novel compounds useful as chemotherapeutic and chemopreventive agents are provided. The compounds are analogs of indole-3-carbinol metabolites wherein the structures and substituents of the compounds are selected to enhance the compounds' overall efficacy, particularly with respect to therapeutic activity, oral bioavailability, long-term safety, patient tolerability, and therapeutic window. The compounds are useful not only in treatment of cancer but also in prevention of cancer. One preferred class of the novel compounds have the structure of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are defined herein. Pharmaceutical compositions are provided as well, as are methods of synthesis and use.