926-62-5

Basic information

• Product Name: ISOBUTYLMAGNESIUM BROMIDE
• Synonyms: ISOBUTYLMAGNESIUM BROMIDE;Isobutylmagnesium bromide solution;ISOBUTYLMAGNESIUM BROMIDE, 2.0M SOLUTION IN DIETHYL ETHER;Isobutylmagnesium Bromide 1.0 M In Tetrahydrofuran;Isobutylmagnesium Bromide (17% in Tetrahydrofuran, ca. 1mol/L);Isobutylmagnesium bromide solution 2.0 in diethyl ether;Isobutylmagnesium bromide, 2M solution in diethyl ether, AcroSeal;2-Methylpropylmagnesium bromide
• CAS NO: 926-62-5
• Molecular Formula: C₄H₉BrMg
• Molecular Weight: 161.32
• Product Categories: Classes of Metal Compounds;Grignard Reagents;Grignard Reagents & Alkyl Metals;Mg (Magnesium) Compounds;Synthetic Organic Chemistry;Typical Metal Compounds;AlkylChemical Synthesis;Grignard Reagents;Organic Bases;Organometallic Reagents;Synthetic Reagents;Grignard Reagent
• Mol File: 926-62-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 51-53℃
• Boiling Point: 122-123℃ (0.2 Torr)
• Flash Point: <−30 °F
• Appearance: /
• Density: 0.941 g/mL at 25 °C
• CAS DataBase Reference: ISOBUTYLMAGNESIUM BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: ISOBUTYLMAGNESIUM BROMIDE(926-62-5)
• EPA Substance Registry System: ISOBUTYLMAGNESIUM BROMIDE(926-62-5)

Safety Data

• Hazard Codes: F+,C,Xn
• Statements: 12-14/15-19-22-34-67-66
• Safety Statements: 16-26-36/37/39-45
• RIDADR: UN 3399 4.3/PG 1
• WGK Germany: 1
• HazardClass: 4.2
• PackingGroup: I
• Hazardous Substances Data: 926-62-5(Hazardous Substances Data)

Usage

Chemical Description

Isobutylmagnesium bromide is a specific type of Grignard reagent used in the synthesis of aziridines.

Uses

Isobutylmagnesium bromide (iBuMgBr) is a general Grignard reagent used in the total synthesis of (+)-rishirilide B, glucolipsin A, and (+)-juvabione. It can also be used as a reagent in the synthesis of pyrrolidine-based influenza neuraminidase (NA) inhibitors.

InChI:InChI=1/C4H9.BrH.Mg/c1-4(2)3;;/h4H,1H2,2-3H3;1H;/q;;+1/p-1/rC4H9Mg.BrH/c1-4(2)3-5;/h4H,3H2,1-2H3;1H/q+1;/p-1

Upstream product

• 78-77-3 Isobutyl bromide 
• 2892-94-6 di-iso-butylmagnesium 

Downstream Products

• 2613-61-8 2,4,6-trimethylheptane 
• 40575-41-5 2-methyloctan-4-ol 
• 1560-93-6 2-methylpentadecane 
• 18243-46-4 et(i-bu)beSiCl 
• 7443-70-1 cis-2-methylcyclohexanol 
• 591-23-1 m-methylcyclohexanol 
• 5454-79-5 cis-3-methylcyclohexanol 
• 116530-90-6 1-Isobutyl-3-methyl-cyclohexanol 
• 108-10-1 4-methyl-2-pentanone 
• 538-93-2 1-phenyl-2-methylpropane 
• 20895-16-3 1-(2-Furanyl)-3-methyl-1-butanone 
• 108-83-8 diisobutyl ketone 
• 1116-39-8 triisobutylborane 
• 592-13-2 2,5-dimethylhexane 

Relevant articles and documents

Identification of Novel Fragments Binding to the PDZ1-2 Domain of PSD-95

Inhibition of PSD-95 has emerged as a promising strategy for the treatment of ischemic stroke, as shown with peptide-based compounds that target the PDZ domains of PSD-95. In contrast, developing potent and drug-like small molecules against the PSD-95 PDZ domains has so far been unsuccessful. Here, we explore the druggability of the PSD-95 PDZ1-2 domain and use fragment screening to investigate if this protein is prone to binding small molecules. We screened 2500 fragments by fluorescence polarization (FP) and validated the hits by surface plasmon resonance (SPR), including an inhibition counter-test, and found four promising fragments. Three ligand efficient fragments were shown by 1H,15N HSQC NMR to bind in the small hydrophobic P0 pockets of PDZ1-2, and one of them underwent structure-activity relationship (SAR) studies. Overall, we demonstrate that fragment screening can successfully be applied to PDZ1-2 of PSD-95 and disclose novel fragments that can serve as starting points for optimization towards small-molecule PDZ domain inhibitors.

METHOD FOR PREPARING DI-ORGANO-DIALKOXYSILANES

The present invention relates to a method for preparing di-organo-dialkoxysilanes, in particular di-organo-dialkoxysilanes wherein one or both of the organic substituents are bulky. The method comprises reacting a tetraalkoxysilane compound with a first Grignard reagent to form a mono-organo-tri-alkoxysilane compound, which is then reacted with a chlorinating agent to form a chlorinated mono-organo-di-alkoxysilane which is then reacted with a second Grignard reagent to form the di-organo-di-alkoxysilane compound.

Perfumes comprising 3-alkylcycloalkanols

Perfumes and perfumed products comprising 3-alkylcycloalkan-1-ols of formula (I), wherein R1represents hydrogen or a methyl, ethyl or propyl group; R2, R4and R5independently represent hydrogen or a methyl group; R3represents a saturated hydrocarbon group with 4-8 carbon atoms, provided that the first carbon atom of this hydrocarbon group is not a tertiary carbon atom, and n represents the numbers 1, 2 and 3. The invention also concerns compounds of formula (I) wherein R1represents a methyl, ethyl or propyl group and R2-R5are as outlined above.