92878-95-0

Basic information

• Product Name: 2-(3-CHLOROPROPOXY)-1-METHOXY-4-NITROBENZENE
• Synonyms: 2-(3-CHLOROPROPOXY)-1-METHOXY-4-NITROBENZENE
• CAS NO: 92878-95-0
• Molecular Formula: C₁₀H₁₂ClNO₄
• Molecular Weight: 245.66
• EINECS: 1312995-182-4
• Mol File: 92878-95-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 388.3 °C at 760 mmHg
• Flash Point: 188.6 °C
• Appearance: /
• Density: 1.268 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(3-CHLOROPROPOXY)-1-METHOXY-4-NITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-CHLOROPROPOXY)-1-METHOXY-4-NITROBENZENE(92878-95-0)
• EPA Substance Registry System: 2-(3-CHLOROPROPOXY)-1-METHOXY-4-NITROBENZENE(92878-95-0)

Safety Data

• Hazardous Substances Data: 92878-95-0(Hazardous Substances Data)

Usage

General Description

2-(3-Chloropropoxy)-1-methoxy-4-nitrobenzene is an organic compound with the chemical formula C10H12ClNO4. It is composed of a benzene ring with a nitro and methoxy group attached at the para position, as well as a chloropropoxy group attached at the ortho position. 2-(3-Chloropropoxy)-1-methoxy-4-nitrobenzene is commonly used in the pharmaceutical and agrochemical industries as an intermediate in the synthesis of various drugs and pesticides. It is considered to be a potentially hazardous chemical and should be handled with caution due to its toxicity and potential for harm to human health and the environment.

Upstream product

• 636-93-1 5-nitroguaiacol 
• 109-70-6 1.3-chlorobromopropane 
• 6940-76-7 1-iodo-3-chloro-propane 

Downstream Products

• 846023-54-9 1-[3-(2-methoxy-5-nitrophenoxy)propyl]-4-methylpiperazine 
• 1292318-18-3 4-methoxy-3-(3-morpholinopropoxy)aniline 
• 1292318-17-2 4-[3-(2-methoxy-5-nitrophenoxy)propyl]morpholine 
• 846023-55-0 4-methoxy-3-[3-(4-methylpiperazin-1-yl)propoxy]phenylamine 
• 846023-56-1 2-cyano-N-(2,4-dichloro-5-methoxyphenyl)-3-{4-methoxy-3-[3-(4-methylpiperazin-1-yl)-propoxy]-phenylamino}-acrylamide 
• 380843-75-4 bosutinib 
• 846023-25-4 3-(3-chloropropoxy)-4-methoxyaniline 

Relevant articles and documents

Method for preparing bosutinib intermediate

The invention provides a method for preparing a bosutinib intermediate. The method comprises the following steps: A, adding SM-1, 1-bromo-3-chloropropane and an acid-binding agent into a reaction solvent, controlling the temperature until the reaction is

HISTONE METHYLTRANSFERASE INHIBITORS

The present disclosure provides certain angular tricyclic compounds that are histone methyltransi erases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinpathies (e.g., beta- thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Process for preparation of 4-amino-3-quinolinecarbonitriles

This invention discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile comprising combining an amine compound with a cyanoacetic acid and an acid catalyst to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline in an alcoholic solvent and a trialkylorthoformate to yield a 3-amino-2-cyanoacrylamide; combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride in acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 4-amino-3-quinolinecarbonitrile and also discloses a process for the preparation of a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile comprising combining a disubstituted 3-amino thiophene with a cyanoacetamide and trialkylorthoformate in an alcoholic solvent to obtain a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride and acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile and also discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile by combining an amine compound with a cyanoacetic acid and a peptide coupling reagent to obtain a suspension; filtering the suspension to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline, an alcoholic solvent, and triethylorthoformate to yield a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride to yield a 4-amino-3-quinolinecarbonitrile.