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93-10-7

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93-10-7 Usage

Chemical Properties

light brown needle-like crystalline powder

Uses

Different sources of media describe the Uses of 93-10-7 differently. You can refer to the following data:
1. For the determination of copper, zinc and uranium with which it forms insoluble salts.
2. 2-?Quinolinecarboxylic acid can be found in the studying of ligands for the purpose of copper-catalyzed Ullmann reactions with aryl ethers and aryl iodides.

Definition

ChEBI: A quinolinemonocarboxylic acid having the carboxy group at the 2-position.

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 1840, 1946 DOI: 10.1021/ja01213a045

General Description

Quinaldic acid is also referred as quinoline-2-carboxylic acid. Microwave-assisted preparation of substituted anilides of quinaldic acid has been reported. It inhibits the oxidation of pyruvate, α-ketoglutarate, glutamate and citrate in rat liver mitochondria. Quinaldic acid is a metabolite of tryptophan degradation and inhibits the gluconeogenesis in perfused livers.

Purification Methods

Crystallise quinaldic acid from *C6H6 or AcOH. It is used for the estimation of many metals. The methyl ester has m 86-87o (from hexane) and pK25 1.76. [Chauduri et al. Frez Z Anal Chem 281 361 1976, Beilstein 22 H 71, 22 II 55, 22 III/IV 1149, 22/3 V 183.]

Check Digit Verification of cas no

The CAS Registry Mumber 93-10-7 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 3 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 93-10:
(4*9)+(3*3)+(2*1)+(1*0)=47
47 % 10 = 7
So 93-10-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H7NO2/c12-10(13)9-6-5-7-3-1-2-4-8(7)11-9/h1-6H,(H,12,13)/p-1

93-10-7 Well-known Company Product Price

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  • Alfa Aesar

  • (A10192)  Quinaldic acid, 98%   

  • 93-10-7

  • 5g

  • 694.0CNY

  • Detail
  • Alfa Aesar

  • (A10192)  Quinaldic acid, 98%   

  • 93-10-7

  • 25g

  • 3309.0CNY

  • Detail
  • Alfa Aesar

  • (A10192)  Quinaldic acid, 98%   

  • 93-10-7

  • 100g

  • 5881.0CNY

  • Detail
  • Aldrich

  • (160660)  Quinaldicacid  98%

  • 93-10-7

  • 160660-2.5G

  • 645.84CNY

  • Detail
  • Aldrich

  • (160660)  Quinaldicacid  98%

  • 93-10-7

  • 160660-10G

  • 1,757.34CNY

  • Detail

93-10-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name quinaldic acid

1.2 Other means of identification

Product number -
Other names Quinaldic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:93-10-7 SDS

93-10-7Relevant articles and documents

Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer

Wang, Ao,Wang, Yawan,Meng, Xin,Yang, Yushe

, (2021/01/07)

Prostate cancer (PC) is the most common malignancy in men worldwide. Here, two series of novel thiohydantoin derivatives of enzalutamide as potent androgen receptor (AR) antagonists were designed and synthesized. Among them, compound 31c was identified as an AR antagonist which is 2.3–fold more potent than enzalutamide. Molecular docking studies were performed to explain the improved potency of 31c at AR. In cell proliferation assays, 31c exhibited similar anti-proliferative activities with enzalutamide against hormone sensitive LNCaP cells and AR-overexpressing LNCaP/AR cells. These data indicate that 31c can be a good lead compound for further structure optimization for the treatment of prostate cancer.

Repurposing an Aldolase for the Chemoenzymatic Synthesis of Substituted Quinolines

Fansher, Douglas J.,Granger, Richard,Kaur, Satinderpal,Palmer, David R. J.

, p. 6939 - 6943 (2021/06/28)

Quinoline derivatives are important natural products and pharmaceuticals, but their synthesis can be challenging due to poor yields, harsh reaction conditions, and instability of starting materials. Here we report the chemoenzymatic synthesis of quinaldic acids under mild conditions using an aldolase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (NahE, or HBPA). A series of 2-aminobenzaldehydes derived from reduction of the corresponding nitro analogue were reacted with pyruvate in the presence of NahE to give substituted quinolines in up to 93% isolated yield. This reaction differs from the aldol condensation catalyzed by NahE in vivo, instead resembling the heterocycle formation catalyzed by its homologue, dihydrodipicolinate synthase.

Method for preparing aromatic carboxylic acid compound

-

Paragraph 0085-0086; 0132-0135; 0176, (2020/02/14)

The invention discloses a method for preparing an aromatic carboxylic acid compound. The method comprises the following steps: 1) heating carbon dioxide and hydrosilane in the presence of a copper catalyst in a reaction medium A; and 2) adding a reaction medium B, aryl halide, a palladium catalyst and a base to the reaction mixture in the step 1), sealing the reaction system, and performing a heating reaction. The method has the advantages that raw materials are simple and easy to obtain, the raw materials are cheap and stable, the catalyst is common, easy to obtain and stable, the reaction conditionsaremild, the aftertreatment is simple, the yield is high, and the like.

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