934343-40-5

Basic information

• Product Name: C₂₃H₂₃ClN₂O₆
• Synonyms: C₂₃H₂₃ClN₂O₆
• CAS NO: 934343-40-5
• Molecular Weight: 458.898
• Mol File: 934343-40-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₃ClN₂O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₃ClN₂O₆(934343-40-5)
• EPA Substance Registry System: C₂₃H₂₃ClN₂O₆(934343-40-5)

Safety Data

• Hazardous Substances Data: 934343-40-5(Hazardous Substances Data)

Upstream product

• 6807-44-9 N-methyl-N-methyloxycarbonylaminomethyl chloride 
• 53-86-1 [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid 

Downstream Products

• 50-00-0 formaldehyd 
• 6642-30-4 methyl N-methylcarbamate 
• 53-86-1 [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid 

Relevant articles and documents

N-Alkyl-N-alkyloxycarbonylaminomethyl (NANAOCAM) prodrugs of carboxylic acid containing drugs

Synthesis and hydrolysis in aqueous buffers of novel N-alkyl-N-alkyloxycarbonylaminomethyl (NANAOCAM) and N-aryl-N-alkyloxycarbonylaminomethyl (NArNAOCAM) derivatives of carboxylic acid containing drugs were carried out. The hydrolysis follows a SN1 type mechanism and is dependent on the nucleofugacity of the leaving group. Topical delivery of the NANAOCAM derivative of naproxen from IPM across hairless mice skin was examined in in vitro diffusion cell experiments. The prodrug was 4.5-fold less lipid soluble, 2.4-fold less water soluble and 3.6-fold less permeable than the parent drug.