934664-27-4

Basic information

• Product Name: tert-butyl 2-(1-(benzyloxycarbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate
• Synonyms: tert-butyl 2-(1-(benzyloxycarbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate
• CAS NO: 934664-27-4
• Molecular Formula: C₂₁H₃₀N₂O₅
• Molecular Weight: 390.4733
• Mol File: 934664-27-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 521.2±50.0 °C(Predicted)
• Appearance: /
• Density: 1.243±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 13.62±0.20(Predicted)
• CAS DataBase Reference: tert-butyl 2-(1-(benzyloxycarbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-(1-(benzyloxycarbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate(934664-27-4)
• EPA Substance Registry System: tert-butyl 2-(1-(benzyloxycarbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate(934664-27-4)

Safety Data

• Hazardous Substances Data: 934664-27-4(Hazardous Substances Data)

Usage

General Description

Tert-butyl 2-(1-(benzyloxycarbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate is a chemical compound that belongs to the class of azetidines, which are four-membered heterocycles containing one nitrogen atom. It is a derivative of piperidine, a heterocyclic amine, and contains a benzyl ester group and a tert-butyl group. tert-Butyl 2-(1-(benzyloxycarbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate can be used in organic synthesis as a building block for the preparation of various pharmaceuticals and biologically active molecules. Its structure includes a piperidine ring with a hydroxy group, an azetidine ring, and a tert-butyl ester, which makes it important for medicinal chemistry research and drug development.

Upstream product

• 388077-74-5 rac-N-(tert-butoxycarbonyl)piperidine-2-carboxamide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 75844-69-8 t-butyl piperidinecarboxylate 
• 105258-93-3 N-(Benzyloxycarbonyl)azetidin-3-one 

Downstream Products

• 934665-56-2 (R,S) tert-butyl 2-{1-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzoyl]-3-hydroxy-3-azetidinyl}-1-piperidinecarboxylate 
• 934662-91-6 cobimetinib 
• 1369665-02-0 (S)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl][3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl]methanone hemifumarate 
• 934665-56-2 tert-butyl (S)-2-{1-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzoyl]-3-hydroxy-3-azetidinyl}perhydropyridine-1-carboxylate 
• 934660-93-2 [14C]-GDC-0973 
• 934666-39-4 1,1-dimethylethyl (2R)-2-(3-hydroxyazetidin-3-yl)piperidine-1-carboxylate 
• 934666-39-4 1,1-dimethylethyl (2S)-2-(3-hydroxyazetidin-3-yl)piperidine-1-carboxylate 
• 934665-54-0 1,1-dimethylethyl (2R)-2-(3-hydroxy-1-{[(phenylmethyl)oxy]carbonyl}azetidin-3-yl)piperidine-1-carboxylate 
• 934665-55-1 1,1-dimethylethyl (2S)-2-(3-hydroxy-1-{[(phenylmethyl)oxy]carbonyl}azetidin-3-yl)piperidine-1-carboxylate 
• 934666-39-4 (R,S) tert-butyl 2-(3-hydroxy-3-azetidinyl)-1-piperidinecarboxylate 
• 934665-53-9 1,1-dimethylethyl (2S)-2-(1-{[(phenylmethyl)oxy]carbonyl}-3-{[(2R)-3,3,3-trifluoro-2-(methyloxy)-2-phenylpropanoyl]oxy}azetidin-3-yl)piperidine-1-carboxylate 
• 934665-52-8 1,1-dimethylethyl (2R)-2-(1-{[(phenylmethyl)oxy]carbonyl}-3-{[(2R)-3,3,3-trifluoro-2-(methyloxy)-2-phenylpropanoyl]oxy}azetidin-3-yl)piperidine-1-carboxylate 

Relevant articles and documents

PROCESS FOR THE PRODUCTION OF COBIMETINIB

The present invention relates to a novel route of synthesis for the production of enantiomerically pure Cobimetinib, new intermediates in the synthesis of Cobimetinib and an amorphous Cobimetinib hemifumarate salt comprising a high salt content.

METHODS OF USING MEK INHIBITORS

The present invention provides methods of treating cancer by administering a compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof, in combination with other cancer treatments.

AZETIDINES AS MEK INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES

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