937026-26-1

Basic information

• Product Name: 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoic acid
• Synonyms: 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoic acid
• CAS NO: 937026-26-1
• Molecular Formula: C₁₂H₁₂N₂O₃
• Molecular Weight: 232.24
• Mol File: 937026-26-1.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoic acid(937026-26-1)
• EPA Substance Registry System: 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoic acid(937026-26-1)

Safety Data

• Hazardous Substances Data: 937026-26-1(Hazardous Substances Data)

Usage

Functional Groups

Methoxy group ( -\textOCH3 )
Imidazole ring ( -\textC3\textH4\textN )

Usage

Development of pharmaceutical drugs
Intermediate synthesis for potential anticancer and antifungal medications
Enzyme inhibitor

Applications

Medicinal chemistry
Production of bioactive molecules and pharmaceutical compounds

Upstream product

• 870837-18-6 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde 
• 870838-56-5 1-(4-bromo-2-methoxyphenyl)-4-methyl-1H-imidazole 
• 201230-82-2 carbon monoxide 
• 454-16-0 1-fluoro-2-methoxy-4-nitrobenzene 
• 958245-17-5 1-(2-methoxy-4-nitrophenyl)-4-methyl-1H-imidazole 
• 958245-18-6 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline 
• 41608-64-4 methyl 3-methoxy-4-aminobenzoate 
• 700834-18-0 4-formylamino-3-methoxybenzoic acid methyl ester 
• 870837-20-0 4-[formyl-(2-oxopropyl)amino]-3-methoxybenzoic acid methyl ester 
• 870837-21-1 3-methoxy-4-(4-methylimidazol-1-yl)benzoic acid methyl ester 
• 243128-37-2 4-fluoro-3-methoxybenzonitrile 
• 1243204-92-3 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzonitrile 

Downstream Products

• 937026-27-2 N,3-dimethoxy-N-methyl-4-(4-methyl-1H-imidazol-1-yl)benzamide 
• 1128103-24-1 C₂₄H₂₁FN₄O₃ 
• 1243204-93-4 N-[2-(3-bromophenyl)ethyl]-3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzamide 
• 1243204-06-9 N-{[5-(4-chlorophenyl)-2-thienyl]methyl}-3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzamide 
• 1243204-94-5 N-[2-(4-chlorophenyl)-2-oxoethyl]-3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzamide 
• 1243204-99-0 tert-butyl 2-({[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoyl]amino}acetyl)hydrazinecarboxylate 
• 1314786-68-9 N-[8-(4-fluorophenyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-benzamide 
• 1262197-14-7 C₁₂H₁₁ClN₂O₂*ClH 
• 1242314-39-1 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzohydrazide 
• 1363145-33-8 ethyl 8-(3,4-difluorophenyl)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate 
• 1363146-39-7 ethyl 3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate 
• 1363146-44-4 ethyl 8-chloro-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate 
• 1243203-54-4 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-N-[3-(trifluoromethyl)benzyl]benzamide 
• 1243203-56-6 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-N-[(2-phenyl-1,3-thiazol-5-yl)methyl]benzamide 

Relevant articles and documents

Design and synthesis of bicyclic heterocycles as potent γ-secretase modulators

The evolution of amide 3 into conformationally restricted bicyclic triazolo-piperidine 14-S as a γ-secretase modulator is described. This is a potential disease modifying anti-Alzheimer's drug which demonstrated high in vitro and in vivo potency against Aβ42 peptide, reduced lipophilicity and enhanced brain free fraction compared to the previous series.

Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators

We report the discovery and optimization of a novel series of dihydrobenzofuran amides as γ-secretase modulators (GSMs). Strategies for aligning in vitro potency with drug-like physicochemical properties and good microsomal stability while avoiding P-gp mediated efflux are discussed. Lead compounds such as 35 and 43 have moderate to good in vitro potency and excellent selectivity against Notch. Good oral bioavailability was achieved as well as robust brain Aβ42 lowering activity at 100 mg/kg po dose.

NOVEL SUBSTITUTED BICYCLIC TRIAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS

The present invention is concerned with novel substituted bicyclic triazole derivatives of Formula (I) wherein Het1, R1, R2, A1, A2, A3, A4, L1, and L2 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.