93961-29-6

Basic information

• Product Name: methyl 2-(4-chlorophenyl)-2-diazoacetate
• Synonyms: methyl 2-(4-chlorophenyl)-2-diazoacetate
• CAS NO: 93961-29-6
• Molecular Weight: 210.62
• Mol File: 93961-29-6.mol
• Article Data: 58

Chemical Properties

• CAS DataBase Reference: methyl 2-(4-chlorophenyl)-2-diazoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(4-chlorophenyl)-2-diazoacetate(93961-29-6)
• EPA Substance Registry System: methyl 2-(4-chlorophenyl)-2-diazoacetate(93961-29-6)

Safety Data

• Hazardous Substances Data: 93961-29-6(Hazardous Substances Data)

Upstream product

• 52449-43-1 (4-chloro-phenyl)-acetic acid methyl ester 
• 37542-28-2 methyl (p-chlorphenyl)glyoxylate 
• 1878-66-6 4-chlorophenylacetic Acid 
• 941-55-9 4-toluenesulfonyl azide 
• 2158-14-7 4-acetamidobenzenesulfonyl azide 

Downstream Products

• 63096-36-6 (4-chloro-phenyl)-hydroxy-acetic acid methyl ester 
• 32174-34-8 (4-chloro-phenyl)-hydroxy-acetic acid methyl ester 
• 1011458-53-9 ethyl 2-[(5-chloro-2-methoxycarbonylmethyl)phenyl]-2-(phenylthio)acetate 
• 1191034-37-3 methyl (αR,2S)-(4-chlorophenyl)(tetrahydrofuran-2-yl)acetate 
• 86169-28-0 methyl 2-acetamido-2-(4-chlorophenyl)acetate 
• 1206707-18-7 methyl 2-(4-chlorophenyl)-2-(1H-indol-2-yl)acetate 
• 1262227-20-2 methyl 2-(4-(benzyl(methyl)amino)phenyl)-2-(4-chlorophenyl)acetate 

Relevant articles and documents

All-Carbon Tetrasubstituted Olefins Synthesis from Diazo Compounds and Iodonium Ylides under Blue LED Irradiation

A route for the construction of all-carbon tetra-substituted olefins through visible-light promoted coupling of diazo compounds with iodonium ylides was developed. A wide range of all-carbon tetra-substituted olefins was obtained in moderate to good yields. The synthetic values of the current method were further approved by the synthesis of natural isolates modified alkenes and the successful transformation of final olefins into important heterocycles. (Figure presented.).

B(C6F5)3-Catalyzed site-selective N1-alkylation of benzotriazoles with diazoalkanes

Alkylation of benzotriazoles is synthetically challenging, often leading to mixtures of N1 and N2 alkylation. Herein, metal-free catalytic site-selective N1-alkylation of benzotriazoles with diazoalkanes is described in the presence of 10 mol% of B(C6F5)3. These reactions provide N1-alkylated benzotriazoles in good to excellent yields and this protocol is successfully adapted to gram-scale syntheses as well as a derivative with antimicrobial activity.

Visible Light-Promoted Sulfoxonium Ylides Synthesis from Aryl Diazoacetates and Sulfoxides

A visible light-promoted reaction of donor/acceptor diazoalkanes with sulfoxides towards the synthesis of synthetically useful sulfoxonium ylides was reported. The reaction occurred under sole visible light irradiation without the need of any transition-metals or additives, affording the corresponding sulfoxonium ylides in moderate to good yields. The success of late-stage modification of natural isolates or drug candidates, scale-up reaction and transformation of sulfoxonium ylides to other useful molecules further rendered the approach valuable.