94-99-5

Basic information

• Product Name: 2,4-Dichlorobenzyl chloride
• Synonyms: 2,4-dichloro-1-(chloromethyl)-benzen;2,4-Dichloro-1-(chloromethyl)benzene;2,4-dichloro-1-chloromethyl-benzene;-2,4-Trichlorotoluene;benzene,2,4-dichloro-1-(chloromethyl)-;Toluene, alpha2,4-trichloro-;toluene,α,2,4-trichloro-;α,2,4-trichlorotoluene
• CAS NO: 94-99-5
• Molecular Formula: C₇H₅Cl₃
• Molecular Weight: 195.47
• EINECS: 202-381-0
• Product Categories: Aromatic Halides (substituted);Econazole Nitrate;Aromatics;Miscellaneous Reagents
• Mol File: 94-99-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: −2.6 °C(lit.)
• Boiling Point: 248 °C(lit.)
• Flash Point: >230 °F
• Appearance: Clear colorless to very light yellow/Oily Liquid
• Density: 1.407 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0386mmHg at 25°C
• Refractive Index: n20/D 1.576(lit.)
• Storage Temp.: Store below +30°C.
• BRN: 387220
• CAS DataBase Reference: 2,4-Dichlorobenzyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dichlorobenzyl chloride(94-99-5)
• EPA Substance Registry System: 2,4-Dichlorobenzyl chloride(94-99-5)

Safety Data

• Hazard Codes: C,N
• Statements: 34-37-50/53-22
• Safety Statements: 26-36/37/39-45-61-60
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• F: 19
• TSCA: Yes
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 94-99-5(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 94-99-5 differently. You can refer to the following data:
1. 2,4-Dichlorobenzyl chloride is a reagent used in the addition of dichlorobenzene.
2. 2,4-Dichlorobenzyl chloride was used as starting reagent for the synthesis of series of novel 1,2,4-triazolium derivatives.

InChI:InChI=1/C7H5Cl3/c8-4-5-1-2-6(9)3-7(5)10/h1-3H,4H2

Upstream product

• 95-73-8 2,4-dichlorotoluene 
• 1777-82-8 (2,4-dichlorophenyl)methanol 
• 50-84-0 2,4 dichlorobenzoic acid 
• 6574-98-7 2,4-dichlorobenzylnitrile 
• 626-16-4 3-(chloromethyl)benzyl chloride 
• 108-88-3 toluene 

Downstream Products

• 59666-97-6 2,4-dichloro-α-(2,6-dichlorophenyl)benzenepropanenitrile 
• 59666-87-4 2,4-dichloro-α-(2-chlorophenyl)benzenepropanenitrile 
• 64008-22-6 2-(o-Bromphenyl)-3-(2,4-dichlorphenyl)-propionitril 
• 59666-96-5 2,3-bis(2,4-dichlorophenyl)propanenitrile 
• 64008-18-0 2-o-Tolyl-3-(2,4-dichlorphenyl)-propionitril 
• 59666-93-2 2,4-dichloro-α-(4-chlorophenyl)benzenepropanenitrile 
• 90390-15-1 ethyl-(2,4-dichloro-benzyl)-amine 
• 22916-47-8 miconazole 

Relevant articles and documents

Industrial preparation method of 2,4,5-trifluorophenylacetic acid

The invention relates to the technical field of preparation of chemical drug intermediates, and particularly discloses an industrial preparation method of 2,4,5-trifluorophenylacetic acid. The preparation method comprises the following steps: carrying out a nitration reaction, a fluorination reaction, a hydrogenation reduction reaction, a diazotization reaction, a halogenation reaction, a cyaniding reaction, a thermal decomposition reaction and a hydrolysis reaction on 2,4-dichlorotoluene to prepare the 2,4,5-trifluorophenylacetic acid. The method has the advantages of low preparation cost andhigh product yield.

N -Hydroxyphthalimide/benzoquinone-catalyzed chlorination of hydrocarbon C-H bond using N -chlorosuccinimide

The direct chlorination of C-H bonds has received considerable attention in recent years. In this work, a metal-free protocol for hydrocarbon C-H bond chlorination with commercially available N-chlorosuccinimide (NCS) catalyzed by N-hydroxyphthalimide (NHPI) with 2,3-dicyano-5,6-dichlorobenzoquinone (DDQ) functioning as an external radical initiator is presented. Aliphatic and benzylic substituents and also heteroaromatic ones were found to be well tolerated. Both the experiments and theoretical analysis indicate that the reaction goes through a process wherein NHPI functions as a catalyst rather than as an initiator. On the other hand, the hydrogen abstraction of the C-H bond conducted by a PINO species rather than the highly reactive N-centered radicals rationalizes the high chemoselectivity of the monochlorination obtained by this protocol as the latter is reactive towards the C(sp3)-H bonds of the monochlorides. The present results could hold promise for further development of a nitroxy-radical system for the highly selective functionalization of the aliphatic and benzylic hydrocarbon C-H.

6-HYDROXY-2-NAPHTHYLCARBINOL AND PROCESS FOR THE PREPARATION THEREOF

6-Hydroxy-2-naphthylcarbinol useful as a synthetic intermediate for preparation of 6-hydroxy-2-naphthaldehyde represented by the following formula (I), and a method for preparing 6-hydroxy-2-naphthylcarbinol comprising the step of reducing 6-hydroxy-2-naphthalenecarboxylic acid.