94110-86-8

Basic information

• Product Name: ethyl 8-nitro-4-oxo-3,4-dihydroquinoline-3-carboxylate
• Synonyms: ethyl 8-nitro-4-oxo-3,4-dihydroquinoline-3-carboxylate;1,4-dihydro-8-nitro-4-oxo-3-quinolinecarboxylic acid ethyl ester
• CAS NO: 94110-86-8
• Molecular Formula: C12H10N2O5
• Molecular Weight: 262.2182
• Mol File: 94110-86-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 8-nitro-4-oxo-3,4-dihydroquinoline-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 8-nitro-4-oxo-3,4-dihydroquinoline-3-carboxylate(94110-86-8)
• EPA Substance Registry System: ethyl 8-nitro-4-oxo-3,4-dihydroquinoline-3-carboxylate(94110-86-8)

Safety Data

• Hazardous Substances Data: 94110-86-8(Hazardous Substances Data)

Usage

Description

Ethyl 8-nitro-4-oxo-3,4-dihydroquinoline-3-carboxylate is a complex chemical compound belonging to the quinoline class, characterized by the presence of a nitro group, a carbonyl group, and an ethyl ester functional group. It may hold potential in medicinal chemistry due to the pharmacological properties often associated with quinoline derivatives, such as anti-inflammatory and antimicrobial activities.

Uses

Used in Medicinal Chemistry:
Ethyl 8-nitro-4-oxo-3,4-dihydroquinoline-3-carboxylate is used as a potential pharmaceutical agent for its possible anti-inflammatory and antimicrobial properties, leveraging the known pharmacological activities of quinoline derivatives.
Further research and testing are required to determine the specific applications and efficacy of ethyl 8-nitro-4-oxo-3,4-dihydroquinoline-3-carboxylate in various fields, including but not limited to drug development for treating inflammation and infections.

Upstream product

• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 88-74-4 2-nitro-aniline 
• 7255-58-5 <<(2-nitropenyl)amino>methylene>propanedioic acid diethyl ester 

Downstream Products

• 131548-98-6 4-chloro-3-ethoxycarbonyl-8-nitro-quinoline 

Relevant articles and documents

Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice

Experimental evidence suggests that selective CB2 receptor modulators may provide access to antihyperalgesic agents devoid of psychotropic effects. Taking advantage of previous findings on structure-activity/selectivity relationships for a class of 4-quin

QUINOLINE DERIVATIVES AS CASPASE-3 INHIBITOR, PREPARATION FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to new quinoline derivatives of formula (1) or their pharmaceutically acceptable salts with caspase-3 inhibitory activity and their preparation methods, wherein R2 is H; halogen; C1-6alkyl; C 1-6 alkoxy; C1-6 alkoxyalkyl; or C3-6cycloalkyl; R1 is formula (a); -CN; or formula (b); R is H; C6-14aryl unsubstituted or substituted by halogen, C1-6 alkyl, C1-6 alkoxy or amino; 5 - 15 membered heterocyclic group unsubstituted or substituted by halogen, C1-6 alkyl, C1-6 alkoxy or amino; or -(CH2)n-CHR4R5. The present invention relates to a pharmaceutical composition for treating caspase-associated diseases by inhibiting the activity of caspase-3 which comprises the compound of formula (1) or its pharmaceutically acceptable salt.

Synthesis and antiallergic activity of some quinolinones and imidazoquinolinones

A group of 1,4-dihydro-4-oxoquinoline-2- and 3-carboxylic acid esters with nitrogen functionality at the 8-position was synthesized, and 6-oxo-6H-imidazo[4,5,1-ij]quinoline-4- and 5-carboxylic acid esters were elaborated from these. Several of the compoun