94535-50-9Relevant articles and documents
CONTROLLED-DELIVERY CROMAKALIM PRODRUGS
-
Page/Page column 167-169, (2021/06/22)
The present invention provides cromakalim prodrugs, compositions, and their use for the modulation of ATP-sensitive potassium (KATP) channels for therapeutic purposes.
Total synthesis of chromanol 293B and cromakalim via stereoselective amination of chiral benzylic ethers
Ma, Sang-Ho,Kim, Yeon Su,Jung, Jun Min,Boggu, Pulla Reddy,Kim, Seung Chan,Kim, In Su,Jung, Young Hoon
supporting information, (2020/01/21)
Stereoselective benzylic amination reaction is important for their further application as pharmaceuticals and agrochemicals, and other chemical entities. Herein, we describe the diastereoselective amination of 1,2-anti-dialkoxychromane on chromane framewo
Chiral Manganese Aminopyridine Complexes: the Versatile Catalysts of Chemo- and Stereoselective Oxidations with H2O2
Ottenbacher, Roman V.,Talsi, Evgenii P.,Bryliakov, Konstantin P.
, p. 78 - 90 (2017/10/06)
In the last decade, manganese(II) complexes with N-donor tetradentate aminopyridine ligands emerged as efficient catalysts of enantioselective epoxidation of olefins and direct selective oxidation of C?H groups in complex organic molecules, with environmentally benign oxidant hydrogen peroxide. In this personal account, we summarize the progress of these catalysts with regard to ligands design, structure-reactivity correlations, evaluation of the substrate scope, as well as mechanistic studies, shedding light on the nature of active sites and the mechanisms of selective oxygenations. Several practically promising catalytic syntheses with the aid of Mn aminopyridine catalysts are exemplified.
Asymmetric epoxidation of alkenes catalyzed by a porphyrin-inspired manganese complex
Dai, Wen,Li, Jun,Li, Guosong,Yang, Hua,Wang, Lianyue,Gao, Shuang
, p. 4138 - 4141 (2013/09/12)
A novel strategy for catalytic asymmetric epoxidation of a wide variety of olefins by a porphyrin-inspired chiral manganese complex using H 2O2 as a terminal oxidant in excellent yield with up to greater than 99% ee has been successfully developed.
Immobilized dimeric chiral Mn(III) salen complex on short channel ordered mesoporous silica as an effective catalyst for the epoxidation of non-functionalized alkenes
Roy, Tamal,Kureshy, Rukhsana I.,Khan, Noor-Ul H.,Abdi, Sayed H.R.,Sadhukhan, Arghya,Bajaj, Hari C.
experimental part, p. 6314 - 6322 (2012/08/28)
Chiral dimeric Mn(III) salen complex with 1R, 2R-(-)-diaminocyclohexane collar was immobilized on short channel large pore sized silica through a long linker of {(CH2)3-NH-melamine-piperazine} to investigate its performance in enanti
COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS
-
Page/Page column 45-49; 55, (2010/12/31)
The present invention relates to derivatized cyclofructan compounds, compositions comprising derivatized cyclofructan compounds, and methods of using compositions comprising derivatized cyclofructan compounds for chromatographic separations of chemical species, including enantiomers. Said compositions may comprise a solid support and/or polymers comprising derivatized cyclofructan compounds.
Development of new HPLC chiral stationary phases based on native and derivatized cyclofructans
Sun, Ping,Wang, Chunlei,Breitbach, Zachary S.,Zhang, Ying,Armstrong, Daniel W.
experimental part, p. 10215 - 10226 (2010/05/01)
An unusual class of chiral selectors, cyclofructans, is introduced for the first time as bonded chiral stationary phases. Compared to native cyclofructans (CFs), which have rather limited capabilities as chiral selectors, aliphatic-and aromatic-functionalized CF6s possess unique and very different enantiomeric selectivities. Indeed, they are shown to separate a very broad range of racemic compounds. In particular, aliphatic-derivatized CF6s with a low substitution degree baseline separate all tested chiral primary amines. It appears that partial derivatization on the CF6 molecule disrupts the molecular internal hydrogen bonding, thereby making the core of the molecule more accessible. In contrast, highly aromaticfunctionalized CF6 stationary phases lose most of the enantioselective capabilities toward primary amines, however they gain broad selectivity for most other types of analytes. This class of stationary phases also demonstrates high "loadability" and therefore has great potential for preparative separations. The variations in enantiomeric selectivity often can be correlated with distinct structural features of the selector. The separations occur predominantly in the presence of organic solvents.
Asymmetric epoxidation of cis-alkenes mediated by iminium salts: Highly enantioselective synthesis of levcromakalim
Page, Philip C. Bulman,Buckley, Benjamin R.,Heaney, Harry,Blacker, A. John
, p. 375 - 377 (2007/10/03)
(Chemical Equation Presented) A range of cis-substituted olefins has been epoxidized with a new dihydroisoquinolinium salt catalyst, using tetraphenylphosphonium monoperoxysulfate as the stoichiometric oxidant, giving ee's of up to 97%. The reaction has been used as the key step in an enantioselective synthesis of the antihypertensive agent levcromakalim.
Enantiomerically pure epoxychromans via asymmetric catalysis
Lee,Muci,Jacobsen
, p. 5055 - 5058 (2007/10/02)
A practical and highly effective process for the asymmetric epoxidation of several 2,2-dimethylchromene derivatives is reported. Catalysis by Mn(salen) complex 4 in all cases affords epoxychromans with >90% ee, and this method has been applied to the synthesis of two recently developed antihypertensive agents in enantiomerically pure form.
