Welcome to LookChem.com Sign In|Join Free

Cas Database

946511-97-3

946511-97-3

Identification

  • Product Name:2-ethylbutyl (S)-2-aminopropanoate hydrochloride

  • CAS Number: 946511-97-3

  • EINECS:

  • Molecular Weight:209.716

  • Molecular Formula: C9H19NO2*ClH

  • HS Code:

  • Mol File:946511-97-3.mol

Synonyms:2-ethylbutyl (S)-2-aminopropanoate hydrochloride

Post Buying Request Now
Entrust LookChem procurement to find high-quality suppliers faster

Safety information and MSDS

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Acrotein
  • Product Description:L-Alanine2-ethylbutylesterHCl 97%
  • Packaging:25g
  • Price:$ 990
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Aaron Chemicals
  • Product Description:L-Alanine,2-ethylbutylester,hydrochloride(1:1) 97%
  • Packaging:25g
  • Price:$ 216
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Aaron Chemicals
  • Product Description:L-Alanine,2-ethylbutylester,hydrochloride(1:1) 97%
  • Packaging:5g
  • Price:$ 69
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 6 Articles be found

Nucleoside analogue and deuterated substance thereof as well as preparation method and application thereof

-

Paragraph 0073-0077, (2021/04/17)

The invention provides a nucleoside analogue and a deuterated substance thereof as well as a preparation method and an application of the deuterated substance, and belongs to the field of medicinal chemistry. The nucleoside analogue and the deuterated substance thereof are a compound shown as a formula I, or salt thereof, or a stereoisomer thereof, or a prodrug thereof, or a solvate thereof; wherein R1 to R34 are each independently selected from hydrogen or deuterium. The compound disclosed by the invention has a good inhibition effect on hepatitis C virus, MERS virus, SARS virus and novel coronavirus (SARS-CoV-2); moreover, the compound is long in elimination half-life period, capable of reducing the administration frequency of the medicine and improving the use safety, better in pharmacokinetics and good in druggability. Therefore, the compound provided by the invention can be used for preparing medicines for treating related virus infection, and has a good application prospect.

THIARABINE- AND THIARABINE PRODRUG-BASED TREATMENTS

-

Paragraph 00386, (2020/12/29)

The present disclosure is concerned with combination therapies that include sulfur- based nucleotide and nucleoside compounds for the treatment of various cancers such as, for example, sarcomas, carcinomas, hematological cancers, solid tumors, breast cancer, cervical cancer, gastrointestinal cancer, colorectal cancer, brain cancer, skin cancer, prostate cancer, ovarian cancer, bladder cancer, thyroid cancer, testicular cancer, pancreatic cancer, endometrial cancer, melanomas, gliomas, leukemias, lymphomas, chronic myeloproliferative disorders, myelodysplastic syndromes, myeloproliferative neoplasms, and plasma cell neoplasms (myelomas). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

2,4,7-SUBSTITUTED-7-DEAZA-2'-DEOXY-2'-FLUOROARABINOSYL NUCLEOSIDE AND NUCLEOTIDE PRO-DRUGS AND USES THEREOF

-

Paragraph 00348, (2020/12/30)

The present disclosure is concerned with 2,4,7-substituted-7-deaza-2'-deoxy-2'- fluoroarabinosyl nucleoside and nucleotide prodrugs that are capable of inhibiting viral infections and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), herpes simplex virus (HSV), human cytomegalovirus (HCMV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), 229E, NL63, OC43, HKU1, Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus disease 2019 (SARS-CoV-2), using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Catalytic Asymmetric Synthesis of the anti-COVID-19 Drug Remdesivir

Chen, Jianzhong,Huo, Xiaohong,Li, Panpan,Wang, Mo,Wu, Zhengxing,Yuan, Qianjia,Zhang, Lu,Zhang, Wanbin,Zhang, Zhenfeng,Zou, Yashi

supporting information, p. 20814 - 20819 (2020/10/15)

The catalytic asymmetric synthesis of the anti-COVID-19 drug Remdesivir has been realized by the coupling of the P-racemic phosphoryl chloride with protected nucleoside GS441524. The chiral bicyclic imidazole catalyst used is crucial for the dynamic kinetic asymmetric transformation (DyKAT) to proceed smoothly with high reactivity and excellent stereoselectivity (96 % conv., 22:1 SP:RP). Mechanistic studies showed that this DyKAT is a first-order visual kinetic reaction dependent on the catalyst concentration. The unique chiral bicyclic imidazole skeleton and carbamate substituent of the catalyst are both required for the racemization process, involving the phosphoryl chloride, and subsequent stereodiscriminating step. A 10 gram scale reaction was also conducted with comparably excellent results, showing its potential for industrial application.

4'-THIO-NUCLEOTIDE AND -NUCLEOSIDE PRODRUGS FOR THE TREATMENT OF CANCER

-

Paragraph 00423, (2019/11/12)

The present disclosure is concerned with 4'-thio nucleotide and nucleoside compounds for the treatment of various cancers such as, for example, sarcomas, carcinomas, hematological cancers, solid tumors, breast cancer, cervical cancer, gastrointestinal cancer, colorectal cancer, brain cancer, skin cancer, prostate cancer, ovarian cancer, bladder cancer, thyroid cancer, testicular cancer, pancreatic cancer, endometrial cancer, melanomas, gliomas, leukemias, lymphomas, chronic myeloproliferative disorders, myelodysplastic syndromes, myeloproliferative neoplasms, and plasma cell neoplasms (myelomas). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Process route upstream and downstream products

Process route

L-N-Boc-Ala
15761-38-3

L-N-Boc-Ala

2-ethyl-1-butanol
97-95-0

2-ethyl-1-butanol

2-ethylbutyl (S)-2-aminopropanoate hydrochloride
946511-97-3

2-ethylbutyl (S)-2-aminopropanoate hydrochloride

Conditions
Conditions Yield
With chloro-trimethyl-silane; at 20 ℃; for 18h;
85%
With chloro-trimethyl-silane; at 20 ℃; for 18h; Inert atmosphere;
85%
2-ethyl-1-butanol
97-95-0

2-ethyl-1-butanol

2-ethylbutyl (S)-2-aminopropanoate hydrochloride
946511-97-3

2-ethylbutyl (S)-2-aminopropanoate hydrochloride

Conditions
Conditions Yield
L-alanin; 2-ethyl-1-butanol; at 0 ℃; for 0.0833333h;
With thionyl chloride; at 60 ℃; for 10h;
80%
2-ethyl-1-butanol; With thionyl chloride; at 0 ℃; for 1h;
L-alanin; at 0 - 90 ℃; for 16h;
74%
C<sub>14</sub>H<sub>27</sub>NO<sub>4</sub>
1187550-21-5

C14H27NO4

2-ethylbutyl (S)-2-aminopropanoate hydrochloride
946511-97-3

2-ethylbutyl (S)-2-aminopropanoate hydrochloride

Conditions
Conditions Yield
With hydrogenchloride; water; In 1,4-dioxane;
2-ethylbutyl (S)-2-aminopropanoate hydrochloride
946511-97-3

2-ethylbutyl (S)-2-aminopropanoate hydrochloride

Conditions
Conditions Yield
With chloro-trimethyl-silane; In dichloromethane;
78%
L-N-Boc-Ala
15761-38-3

L-N-Boc-Ala

2-ethyl-1-butanol
97-95-0

2-ethyl-1-butanol

2-ethylbutyl (S)-2-aminopropanoate hydrochloride
946511-97-3

2-ethylbutyl (S)-2-aminopropanoate hydrochloride

Conditions
Conditions Yield
With chloro-trimethyl-silane; at 20 ℃; for 18h;
85%
With chloro-trimethyl-silane; at 20 ℃; for 18h; Inert atmosphere;
85%
2-ethyl-1-butanol
97-95-0

2-ethyl-1-butanol

2-ethylbutyl (S)-2-aminopropanoate hydrochloride
946511-97-3

2-ethylbutyl (S)-2-aminopropanoate hydrochloride

Conditions
Conditions Yield
L-alanin; 2-ethyl-1-butanol; at 0 ℃; for 0.0833333h;
With thionyl chloride; at 60 ℃; for 10h;
80%
2-ethyl-1-butanol; With thionyl chloride; at 0 ℃; for 1h;
L-alanin; at 0 - 90 ℃; for 16h;
74%
C<sub>14</sub>H<sub>27</sub>NO<sub>4</sub>
1187550-21-5

C14H27NO4

2-ethylbutyl (S)-2-aminopropanoate hydrochloride
946511-97-3

2-ethylbutyl (S)-2-aminopropanoate hydrochloride

Conditions
Conditions Yield
With hydrogenchloride; water; In 1,4-dioxane;
2-ethylbutyl (S)-2-aminopropanoate hydrochloride
946511-97-3

2-ethylbutyl (S)-2-aminopropanoate hydrochloride

Conditions
Conditions Yield
With chloro-trimethyl-silane; In dichloromethane;
78%

Global suppliers and manufacturers

Global( 41) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • LIDE PHARMACEUTICALS LIMITED
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-25-58409506
  • Emails:lide@lidepharma.com
  • Main Products:56
  • Country:China (Mainland)
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 946511-97-3
Post Buying Request Now
close
Remarks: The blank with*must be completed