946511-97-3

Basic information

• Product Name: 2-ethylbutyl (S)-2-aminopropanoate hydrochloride
• Synonyms: 2-ethylbutyl (S)-2-aminopropanoate hydrochloride
• CAS NO: 946511-97-3
• Molecular Weight: 209.716
• Mol File: 946511-97-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 77 - 79°C
• CAS DataBase Reference: 2-ethylbutyl (S)-2-aminopropanoate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ethylbutyl (S)-2-aminopropanoate hydrochloride(946511-97-3)
• EPA Substance Registry System: 2-ethylbutyl (S)-2-aminopropanoate hydrochloride(946511-97-3)

Safety Data

• Hazardous Substances Data: 946511-97-3(Hazardous Substances Data)

Usage

Uses

L-Alanine 2-Ethylbutyl Ester Hydrochloride is used in the synthesis of phosphoramidate prodrug of a pyrrolo[2,1-f][triazin-4-amino] adenine C-nucleoside (GS-5734) for the treatment of ebola and emerging viruses.

Upstream product

• 15761-38-3 L-N-Boc-Ala 
• 97-95-0 2-ethyl-1-butanol 
• 56-41-7 L-alanin 
• 1187550-21-5 C₁₄H₂₇NO₄ 

Downstream Products

• 1355049-92-1 2-ethylbutyl (2S)-2-{[chloro(phenoxy)phosphoryl]amino}propanoate 

Relevant articles and documents

Nucleoside analogue and deuterated substance thereof as well as preparation method and application thereof

The invention provides a nucleoside analogue and a deuterated substance thereof as well as a preparation method and an application of the deuterated substance, and belongs to the field of medicinal chemistry. The nucleoside analogue and the deuterated substance thereof are a compound shown as a formula I, or salt thereof, or a stereoisomer thereof, or a prodrug thereof, or a solvate thereof; wherein R1 to R34 are each independently selected from hydrogen or deuterium. The compound disclosed by the invention has a good inhibition effect on hepatitis C virus, MERS virus, SARS virus and novel coronavirus (SARS-CoV-2); moreover, the compound is long in elimination half-life period, capable of reducing the administration frequency of the medicine and improving the use safety, better in pharmacokinetics and good in druggability. Therefore, the compound provided by the invention can be used for preparing medicines for treating related virus infection, and has a good application prospect.

2,4,7-SUBSTITUTED-7-DEAZA-2'-DEOXY-2'-FLUOROARABINOSYL NUCLEOSIDE AND NUCLEOTIDE PRO-DRUGS AND USES THEREOF

The present disclosure is concerned with 2,4,7-substituted-7-deaza-2'-deoxy-2'- fluoroarabinosyl nucleoside and nucleotide prodrugs that are capable of inhibiting viral infections and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), herpes simplex virus (HSV), human cytomegalovirus (HCMV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), 229E, NL63, OC43, HKU1, Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus disease 2019 (SARS-CoV-2), using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

4'-THIO-NUCLEOTIDE AND -NUCLEOSIDE PRODRUGS FOR THE TREATMENT OF CANCER

The present disclosure is concerned with 4'-thio nucleotide and nucleoside compounds for the treatment of various cancers such as, for example, sarcomas, carcinomas, hematological cancers, solid tumors, breast cancer, cervical cancer, gastrointestinal cancer, colorectal cancer, brain cancer, skin cancer, prostate cancer, ovarian cancer, bladder cancer, thyroid cancer, testicular cancer, pancreatic cancer, endometrial cancer, melanomas, gliomas, leukemias, lymphomas, chronic myeloproliferative disorders, myelodysplastic syndromes, myeloproliferative neoplasms, and plasma cell neoplasms (myelomas). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.